产后忧郁、产后抑郁患者雌二醇、孕酮和瘦素水平变化的研究

目的:探讨血清雌二醇(E2)、孕酮(P)和瘦素(Leptin)水平变化与产后忧郁、产后抑郁的关系。方法:使用爱丁堡产后抑郁量表和产后抑郁症诊断标准进行诊断,随访500例孕产妇,测定并分析产后忧郁50例、非忧郁50例、产后抑郁16例和非抑郁18例孕产妇的产前、产后及产后42天血清E2、P和Leptin水平。结果:产后忧郁患者的产后E2、P水平明显低于对照组(P<0.01,P<0.05),产后Leptin水平高于对照组(P<0.05);产后抑郁患者的产后42天E2水平明显低于对照组(P<0.05),产后与产后42天P水平差明显高于对照组(P<0.05),产后42天Leptin水平明显高于对照组(P<0.05);忧郁抑郁患者中,产后42天E2水平明显低于单纯产后忧郁患者(P<0.05),Leptin水平明显高于单纯忧郁患者(P<0.05)。结论:低水平的E2、P可能是产后忧郁的病因;低水平的E2和产后42天P下降幅度较大可能是产后抑郁的病因;高血清Leptin水平与产后忧郁、产后抑郁有关。

Study on the levels of Estradiol, Progesterone and Leptin of the patients with postpartum melancholia and depression

Objective:To detect the change of the serum levels of postpartum melancholia,postpartum depression with Estradiol (E2),Progesterone (P) and Leptin.Methods:Using the Edinburgh Postnatal Depression Scale and Diagnostic criteria of postpartum depression for diagnosis,500 cases of pregnant and parturient women were followed-up.50 cases of postpartum melancholia,50 cases of non-postpartum melancholia,16 cases of postpartum depression and 18 cases of non-depressed patients were chosen.The levels of serum E2,Pand Leptin of them were analyzed in pregnant and post-natal women,also their post-natal 42-day Results:The levels of post-natal E2 and P of the postpartum melancholia were significantly lower than the control group (P<0.01,P<0.05),while the level of post-partum Leptin was higher than the control group (P<0.05).After 42 days,the postpartum depression person's E2 level was significantly lower than the control group (P<0.05),thelevel of P was significantly higher than the control group (P<0.05),.the level of Leptin was significantly higher than the control group (P<0.05).Comparing with the patients of postpartum melancholia and depression,the 42-day E2 level of those patients,with postpartum melancholia only,were significantly lower than the latter(P<0.05),the level of Leptin was significantly higher than the latter (P<0.05).Conclusion:The low levels of E2 and Pmay be the reason of postpartum melancholia.The low levels of E2 and a large margin decline of the level of Pafter post-natal 42 days may be the reason of postpartum depression.The high level of serum Leptin is related to postpartum melancholia and postpartum depression.