Suppression of LTP-like plasticity in human motor cortex by the GABAB receptor agonist baclofen |
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| Authors: | Michelle N McDonnell Yuri Orekhov Ulf Ziemann |
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| Affiliation: | (1) Research Centre for Human Movement Control, The University of Adelaide, Adelaide, Australia;(2) Motor Cortex Laboratory, Department of Neurology, Johann Wolfgang Goethe-University, Frankfurt am Main, 60528, Germany;(3) Present address: Laboratory for Psychophysiology, Institute for Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia |
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| Abstract: | Previous experiments in slice preparations revealed that pharmacological activation of GABAB receptors down- or up-regulates long-term potentiation (LTP), depending on whether increase of GABAB receptor mediated inhibitory postsynaptic potentials or decrease of presynaptic auto-inhibition of GABAA receptor mediated inhibition predominates. The effects of GABAB receptor activation on LTP in humans in vivo are unknown. Here we show, by using transcranial magnetic stimulation, that the GABAB receptor agonist baclofen decreases paired associative stimulation induced LTP-like plasticity in human motor cortex. This suggests that increased GABAB mediated inhibitory postsynaptic potentials drive this effect, and that baclofen may have a negative impact on LTP-dependent behavioural processes such as motor learning. |
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| Keywords: | GABAB receptor Baclofen LTP-like plasticity Paired associative stimulation Transcranial magnetic stimulation Human motor cortex |
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