Genetics of atopic dermatitis |
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| Authors: | Caroline Bussmann Stephan Weidinger Natalija Novak |
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| Affiliation: | 1. Department of Dermatology and Allergy, University of Bonn, Germany;2. Department of Dermatology and Allergy, Technical University of Munich, Germany |
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| Abstract: | Atopic dermatitis (AD) is a multifactorial disease, with a strong genetic predisposition. Genome‐wide studies as well as candidate gene studies revealed several susceptibility loci. Since the observation of a strong association of “loss of function” mutations in the filaggrin gene with AD, the epidermal barrier was rediscovered as important pathophysiological co‐factor of this disease. |
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| Keywords: | atopic dermatitis genetics filaggrin epidermal barrier polymorphisms |
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