| 自然杀伤细胞治疗晚期肝癌的近期临床疗效 |
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| 引用本文： | 荆娜,张金超,杨岩丽,吴琼,孙雪冬,张晓燕,赵来伟,潘欣,蒋昊,丁国梁,王丹红,陈虎. 自然杀伤细胞治疗晚期肝癌的近期临床疗效[J]. 中国肿瘤生物治疗杂志, 2016, 23(4): 515-518. DOI: 10.3872/j.issn.1007-385X.2016.04.010 |
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| 作者姓名： | 荆娜 张金超 杨岩丽 吴琼 孙雪冬 张晓燕 赵来伟 潘欣 蒋昊 丁国梁 王丹红 陈虎 |
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| 作者单位： | 1. 国防大学医院 内科,北京100091;军事医学科学院附属307医院 造血干细胞移植研究所,北京100071;2. 军事医学科学院附属307医院 造血干细胞移植研究所,北京,100071 |
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| 基金项目： | 国家科技重大专项“十二五”计划基金资助项目（No.2009zx09503） |
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| 摘 要： | 目的:评价自然杀伤(natural killer,NK)细胞治疗晚期肝癌的近期临床疗效、安全性以及其对肝癌患者外周血淋巴细胞亚群和NK细胞活性的影响.方法:采集解放军307医院2013年9月至2015年9月所收治的30例晚期肝癌患者的外周血,经体外培养诱导产生NK细胞,于第14、15天进行细胞回输,连续2次回输为1疗程,共进行2个疗程治疗,分别于每疗程细胞治疗前及治疗完成2周后取患者外周血检测淋巴细胞亚群及NK细胞活性,比较治疗前、后各淋巴细胞亚群与NK细胞比例的变化,观察与临床疗效的关系.结果:30例晚期肝癌患者经NK细胞治疗后PR 4例,SD 19例,PD 7例;客观缓解率为13.3％,疾病控制率为76.7％;细胞免疫治疗前后淋巴细胞亚群无明显变化,NK细胞活性较治疗前明显提高[(6.68±3.83)％ vs (5.06±4.46)％,P＜O.05].治疗过程中30例患者均未出现不良反应.结论:NK细胞免疫治疗可提高机体抗肝癌免疫效应,可减缓病情进展,安全性高,为晚期肝癌患者开辟一条新的治疗途径.
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| 关 键 词： | 自然杀伤细胞 肝癌 临床疗效 |
| 收稿时间： | 2016-02-03 |
| 修稿时间： | 2016-05-24 |
Natural killer cell treatment for advanced hepatocellular carcinoma patients: an observation of recent clinical curative effect |
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| JING N,ZHANG Jinchao,YANG Yanli,WU Qiong,SUN Xuedong,ZHANG Xiaoyan,ZHAO Laiwei,PAN Xin,JIANG Hao,DING Guoliang,WANG Danhong and CHEN Hu. Natural killer cell treatment for advanced hepatocellular carcinoma patients: an observation of recent clinical curative effect[J]. Chinses Journal of Cancer Biotherapy, 2016, 23(4): 515-518. DOI: 10.3872/j.issn.1007-385X.2016.04.010 |
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| Authors: | JING N ZHANG Jinchao YANG Yanli WU Qiong SUN Xuedong ZHANG Xiaoyan ZHAO Laiwei PAN Xin JIANG Hao DING Guoliang WANG Danhong CHEN Hu |
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| Affiliation: | Department of Internal Medicine, Hospital of National Defense University of PLA, Beijing 100071, China;Institution of Hematopoietic Stem Cell Transplantation, No. 307 Hospital of PLA Affiliated to Academy of Military Medical Sciences, Beijing 100071, China,Institution of Hematopoietic Stem Cell Transplantation, No. 307 Hospital of PLA Affiliated to Academy of Military Medical Sciences, Beijing 100071, China,Institution of Hematopoietic Stem Cell Transplantation, No. 307 Hospital of PLA Affiliated to Academy of Military Medical Sciences, Beijing 100071, China,Institution of Hematopoietic Stem Cell Transplantation, No. 307 Hospital of PLA Affiliated to Academy of Military Medical Sciences, Beijing 100071, China,Institution of Hematopoietic Stem Cell Transplantation, No. 307 Hospital of PLA Affiliated to Academy of Military Medical Sciences, Beijing 100071, China,Institution of Hematopoietic Stem Cell Transplantation, No. 307 Hospital of PLA Affiliated to Academy of Military Medical Sciences, Beijing 100071, China,Institution of Hematopoietic Stem Cell Transplantation, No. 307 Hospital of PLA Affiliated to Academy of Military Medical Sciences, Beijing 100071, China,Institution of Hematopoietic Stem Cell Transplantation, No. 307 Hospital of PLA Affiliated to Academy of Military Medical Sciences, Beijing 100071, China,Institution of Hematopoietic Stem Cell Transplantation, No. 307 Hospital of PLA Affiliated to Academy of Military Medical Sciences, Beijing 100071, China,Institution of Hematopoietic Stem Cell Transplantation, No. 307 Hospital of PLA Affiliated to Academy of Military Medical Sciences, Beijing 100071, China,Institution of Hematopoietic Stem Cell Transplantation, No. 307 Hospital of PLA Affiliated to Academy of Military Medical Sciences, Beijing 100071, China and Institution of Hematopoietic Stem Cell Transplantation, No. 307 Hospital of PLA Affiliated to Academy of Military Medical Sciences, Beijing 100071, China |
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| Abstract: | |
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| Keywords: | natural killer (NK) cell hepatocellular carcinoma clinical curative efficacy |
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