冰片-中空介孔二氧化硅球载药体系的制备及对冰片挥发性影响的研究

采用硬模板法制备了尺寸约为300 nm,外壳厚度约25 nm的中空介孔二氧化硅球(HMSNs),通过溶剂浸渍法将易挥发药物冰片包载其中,以期解决冰片的药剂学稳定问题,并利用BET,TEM,FT-IR等对HMSNs以及载药体系进行了表征,考察了载药体系的最佳载药时间,最大载药量以及冰片的挥发状况。研究结果显示,室温、中性条件下制备的HMSNs球形度良好,可以在较短的时间内实现对冰片较大的载药量,6 h内载药量高达74.04%,同时体系中冰片的挥发性得到了很大程度的改善。该新型载药体系的研究为冰片在中药制剂中的广泛应用提供了新思路。

Preparation of borneol loaded hollow mesoporous silica nanoparticles and effect on borneol volatility

The hollow mesoporous silica nanoparticles (HMSNs) were prepared by hard template method, with a size of 300 nm and shell thickness of 25 nm. Borneol was loaded with solvent impregnation method in order to solve the stability problem of borneol in pharmaceutics, and the BET, TEM and FT-IR were used to characterize the HMSNs and the borneol-HMSNs drug delivery system. The optimal drug loading time, maximum drug loading capacity and the volatility of borneol were investigated. The results showed that HMSNs which were prepared at room temperature and neutral conditions had good sphericity, achieved high drug loading of borneol in a short time, and the drug loading was up to 74.04% within 6 hours; meanwhile, volatility of borneol in the system was greatly improved. This novel drug delivery system provides a new idea for wide application of borneol in the traditional Chinese medicine.