胃宁茶袋泡剂联合奥美拉唑治疗肝胃不和型反流性食管炎疗效观察

目的:观察胃宁茶袋泡剂联合奥美拉唑治疗肝胃不和型反流性食管炎的疗效,并探讨其机制。方法:将64例肝胃不和型反流性食管炎患者随机分为治疗组与对照组,各32例。两组均以奥美拉唑为基础治疗,治疗组加用胃宁茶袋泡剂泡服,对照组加用莫沙比利分散片口服,4周为1疗程,两组均治疗1疗程。观察治疗前后临床症状积分、内镜下食管炎症程度及胆汁反流情况、血浆胃动素及前列腺素E2水平等。结果:治疗后两组患者内镜积分较治疗前明显降低(P0.05);两组内镜下食管炎症疗效比较治疗组优于对照组(P0.05)。治疗后两组症状积分较治疗前明显降低(P0.05,P0.01),治疗组优于对照组(P0.05)。两组证候疗效比较治疗组优于对照组(P0.05),治疗组治疗后血浆胃动素水平升高优于对照组(P0.05)。治疗组治疗前后血浆前列腺素水平明显升高(P0.05)。治疗组治疗后胃镜下胆汁消失率优于对照组(P0.05)。结论:胃宁茶袋泡剂为治疗肝胃不和型反流性食管炎的有效中药制剂,其作用机制可能与增加胃动力、减少胆汁反流、调节胃肠激素等有关。

Effect of Weining Tea Bag and Omeprazole on Liver and Stomach Disharmony Reflux Esophagitis

Objective: To observe the curative effect of Weining tea bag and omeprazole in treatment of liver and stomach disharmony reflux esophagitis. Method: The 64 cases of liver and stomach disharmony reflux esophagitis were randomly divided into treatment group (32 cases) and control group (32 cases). The patients in both groups took omeprazole as the basis treatment, and patients in treatment group received additional Weining tea bag while patients in control group received additional Mosapride dispersible tablets, 4 weeks as a course of treatment, and both groups were treated for 1 course of treatment. The clinical symptom scores, degree of endoscopic esophageal inflammation, bile reflux, plasma motilin and prostaglandin E₂ levels were observed before and after treatment. Result: The endoscopic scores after treatment were significantly reduced in both groups (P<0.05), treatment group was superior to the control group in efficacy on endoscopic esophageal inflammation (P<0.05). The symptom scores were significantly reduced in both groups after treatment (P<0.05, P<0.01), and the effect in treatment group was better than that in control group (P<0.05). Treatment group was superior to control group in the syndrome efficacy (P<0.05). The increase in plasma motilin level in treatment group was superior to that in control group after treatment (P<0.05). The level of plasma prostaglandin was significantly increased in the treatment group after treatment (P<0.05). The disappearance rate of bile under gastroscope in treatment group was superior to that in control group after treatment (P<0.05). Conclusion: Weining tea bag is an effective Chinese medicine for liver and stomach disharmony reflux esophagitis, and the mechanism may be associated with increasing gastric motility, reducing bile reflux, and regulating gastrointestinal hormones.