| 过氧化脂质对体外循环中红细胞的影响 |
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| 引用本文： | 贾兵,张善通,李歌丰,曹金红,陈张根,王人荣,李文彦. 过氧化脂质对体外循环中红细胞的影响[J]. 复旦学报(医学版), 1994, 0(4) |
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| 作者姓名： | 贾兵 张善通 李歌丰 曹金红 陈张根 王人荣 李文彦 |
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| 作者单位： | 上海医科大学儿科医院心胸外科 |
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| 摘 要： | 以１４例小儿体外循环（ＣＰＢ）心内直视手术病例为对象，研究ＣＰＢ中过氧化脂质（ＬＰＯ）与红细胞损伤之间的关系。发现ＣＰＢ使血浆游离血红蛋白（ＰＦ－Ｈｂ）明显升高，扫描电镜见红细胞形态发生改变，体积增大，红细胞表面积与体积之比值下降，提示ＣＰＢ可造成红细胞破坏。血浆ＬＰＯ在ＣＰＢ期间明显升高，且与ＰＦ－Ｈｂ呈直线相关关系，ｒ＝０．７８，Ｐ＜０．０５，说明氧自由基介导的脂质过氧化损害是造成体外循环中红细胞破坏的因素之一。
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| 关 键 词： | 体外循环，过氧化脂质，红细胞损伤 |
LIPID PEROXIDE DAMAGE OF ERYTHROCYTES IN PATIENTS UNDERGOING CARDIOPULMONARY BYPASS |
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| Jia Bin,Zhang Shantong,Li Gefeng, Cao Jinhong,Chen Zhanggen,Wang Renrong, Li Wenyan. LIPID PEROXIDE DAMAGE OF ERYTHROCYTES IN PATIENTS UNDERGOING CARDIOPULMONARY BYPASS[J]. Fudan University Journal of Medical Sciences, 1994, 0(4) |
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| Authors: | Jia Bin Zhang Shantong Li Gefeng Cao Jinhong Chen Zhanggen Wang Renrong Li Wenyan |
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| Abstract: | We measured plasma lipid peroxide(P-LPO),plasma free hemoglobin(PFHb)and morphological parameters of red blood cells in 14 patients undergoing cardiopulmonary bypass(CPB).The results revealed that P-LPO and PF-Hb increased gradually during CPB.The highest level of P-LPO attained, preceded that of PF-Hb.Red blood cells became rounded,and the surface area-volume ratio was decreased.Linear regression analysis showed that there is a positive linear correlation between P-LPO and PF-Hb.We conclude that oxygen free radicals are generated by several mechanisms during CPB and it plays an important role in erythrocytic injury. |
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| Keywords: | cardiopulmonary bypass lipid peroxide erythrocytes injury |
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