Influence of ionic disturbances produced by gastric washing on cortical spreading depression |
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| Authors: | Rubem Carlos Araujo Guedes Romualdo José do Carmo |
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| Affiliation: | (1) Instituto de Biofísica, Universidade Federal do Rio de Janeiro, 20.000 Rio de Janeiro, Brasil;(2) Centro de Ciências da Saude, Cidade Universitária, 20.000 Rio de Janeiro, Brasil;(3) Present address: Abteilung Neurobiologie, Max-Planck-Institut für biophysikalische Chemie, Postfach 968, D-3400 Göttingen, Federal Republic of Germany |
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| Abstract: | Summary The ionic composition of the internal environment was altered in rabbits by means of gastric washing, combined with intramuscular administration of 3-Beta-aminoethylpyrazole. The effects of this treatment on cortical spreading depression (SD) were studied. C1- and Na+ concentrations decreased significantly in serum and in cerebrospinal fluid after the treatment. This made the animals much more susceptible to SD, as established by the high incidence of  spontaneous SD, increased SD velocity of propagation and facilitated its interhemispheric transfer. An intensification of the epileptiform activity associated with SD was also observed. Intravenous replacement of NaCl abolished the above effects on SD. When the intravenous replacement was done with Na-Isethionate, those effects were enhanced. It is concluded that chloride deficiency was the main factor responsible for the observed facilitating effects.This work was supported by grants from the BNDE (FUNTEC-74 e 143), CNPq and CAPES |
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| Keywords: | Spreading depression Gastric washing Cl- deficiency Rabbit |
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