脂肪组织的内分泌功能研究进展

脂肪组织是机体储存能量的主要场所，在机体需要时动员，释放能量。但是近几年的研究发现，脂肪组织还是一个活跃的内分泌器官。已有的研究发现脂肪组织可以分泌一系列激素和细胞因子，参与调节一些生理病理过程，与2型糖尿病、肥胖、心血管疾病、免疫反应等疾病和病理过程有密切的关系。本文将对今年来的一些研究进展作一综述。

Adipose tissue as a endocrine organ

This classical view of adipose tissue as a rather specialized passive storage organ. Starting with the discovery of leptin as an adipocyte - derived satiety factor, adipose tissue is increasingly being recognized as an endocrineorgan. A growing number of adipocyte - derived factors have been described and their contribution to the pathophysiology of the metabolic syndrome, characterized by, insulin resistance, dyslipidemia, hypertension, chronic inflammationstate, is being investigated. This review focuses on recent advances in the physiology and pharmacology of adipose -derived factors with particular emphasis on their therapeutic potential.