Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopenias |
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| Authors: | Suzanne M Vercauteren Ali Bashashati Donghong Wu Ryan R Brinkman Connie Eaves Allen Eaves Aly Karsan |
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| Institution: | 1. Food, Nutrition and Health, University of British Columbia, 2205 East Mall, Vancouver, BC V6T 1Z4, Canada;2. Children''s & Women''s Health Centre of British Columbia, Division of Hematopathology, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada;3. Helen Keller International, Cambodia Country Office, P.O. Box 168, Phnom Penh, Cambodia |
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| Abstract: | We studied the diagnostic role of CFC assays in myelodysplastic syndromes (MDS) using CFC data from bone marrow (BM) and peripheral blood (PB) of 221 MDS patients, 51 patients with non-malignant causes of cytopenia and/or dysplasia and 50 normal controls. A consistent decrease in BM but not PB multi-lineage and erythroid progenitor frequencies was seen in patients with MDS compared to controls (P < 0.05). Automated distinction showed a sensitivity of 87 ± 6% and a specificity of 71 ± 11% in classifying MDS patients. In conclusion, a defect in early hematopoietic progenitor activity, in particular erythroid activity, distinguishes MDS from non-MDS. |
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| Keywords: | Myelodysplastic syndromes CFC Hematopoietic progenitors Diagnostic criteria |
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