| 辛伐他汀对apoE-/-小鼠心肌肥厚的抑制作用及其机制探讨 |
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| 引用本文： | 刘明,虞莹,曹全,张磊,贾剑国,姜红,邹云增,葛均波.辛伐他汀对apoE-/-小鼠心肌肥厚的抑制作用及其机制探讨[J].中国分子心脏病学杂志,2011,11(5):297-301. |
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| 作者姓名： | 刘明 虞莹 曹全 张磊 贾剑国 姜红 邹云增 葛均波 |
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| 作者单位： | 200032,上海市 复旦大学附属中山医院上海市心血管疾病研究所 |
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| 基金项目： | 2008年杨森科学研究基金; Jansen Research Council China~~ |
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| 摘 要： | 目的探讨辛伐他汀对高脂喂养的 apo E-/-小鼠心肌肥厚及氧化应激分子的影响。方法 5 周龄雄性 apo E-/-小鼠和 C57 小鼠,分为野生型组 (Wild)、apo E-/-小鼠组 (Apo E)及 apo E-/-小鼠+辛伐他汀组 (Apo E-S),予以高脂喂养。8 周龄开始分别给药,干预 3 周后测量舒张期左室前壁厚度 (LVAWd)、舒张期左室后壁厚度 (LVPWd)、心脏体重比 (HW/BW)、左室横截面面积 (LVCSA) 和心肌心房钠尿肽 (ANP) 蛋白表达等心肌肥厚参数及心肌 ROS 水平、p22phox 和 p47phox 蛋白表达等氧化应激指标。结果 Apo E 组 LVAWd 、LVPWd、HW/BW、LVCSA、ANP、ROS、p22phox 及 p47phox 水平均明显高于 Wild 组 (p<0.05),而 Apo E-S 组上述指标均显著低于 Apo E 组 (p<0.05)。结论辛伐他汀可能通过抗氧化应激作用改善高脂饮食条件下 apo E-/-小鼠心肌肥厚。
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| 关 键 词： | apo E-/-小鼠 辛伐他汀 氧化应激 心肌肥厚 |
Inhibitory effects of Simvastatin on cardiac hypertrophy in western diet fed apo E-/-mice |
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| LIU Ming
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YU ying
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CAO Quan
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ZHANG Lei
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JIA Jian-guo
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JIANG Hong
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ZOU Yun-zeng
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GE Jun-bo.Inhibitory effects of Simvastatin on cardiac hypertrophy in western diet fed apo E-/-mice[J].Molecular Cardiology of China,2011,11(5):297-301. |
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| Authors: | LIU Ming YU ying CAO Quan ZHANG Lei JIA Jian-guo JIANG Hong ZOU Yun-zeng GE Jun-bo |
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| Institution: | LIU Ming,YU ying,CAO Quan,ZHANG Lei,JIA Jian-guo,JIANG Hong,ZOU Yun-zeng,GE Jun-bo.Shanghai Institute of Cardiovascular Disease,Zhongshan Hospital,Fudan University,200032,China |
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| Abstract: | Objective To explore the effects of Simvastatin on cardiac hypertrophy in apo E-/-mice fed western diet and the possible mechanism.Methods Five-week-old male apo E-/-mice and C57BL/6J mice were divided into wild group(Wild),apo E-/-mice group(Apo E) and apo E-/-mice +simvastatin group(Apo E-S).All mice were fed western diet for 3 weeks.Then,mice were given either placebo(Wild and Apo E group) or oral simvastatin(50 mg/kg/day)(Apo E-S group).After 3 weeks of treatment,the cardiac hypertrophy values and the o... |
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| Keywords: | Apo E-/-Mice Simvastatin Oxidative Stress Cardiac hypertrophy |
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