苦碟子注射液联合神经节苷脂治疗急性脑梗死的临床研究

目的:观察苦碟子注射液联合神经节苷脂治疗急性脑梗死的临床疗效和安全性。方法:将脑梗死患者180例随机分为观察组和对照组各90例。2组患者均采用基础治疗,观察组在基础治疗的同时加用苦碟子注射液联合神经节苷脂治疗,对照组在基础治疗的同时加用神经节苷脂治疗。观测2组患者血液流变学变化情况及NIHSS评分、Bar t hel评分、临床疗效、不良反应。结果:观察组患者临床疗效、NIHSS评分、Bar t hel评分、血液学指标均优于对照组,差异具有统计学意义(P0.05);治疗过程中2组患者均未见有临床意义的异常改变及明显毒副反应。结论:苦碟子注射液联合神经节苷脂治疗急性脑梗死可以有效改善急性脑梗死患者的血液流变学,提高临床疗效。

Clinical Study onKuDieZiInjection Combined with Ganglioside in Treating Acute Cerebral Infarction

Objective: To investigate clinical efficacy and the safety ofKuDieZiinjection combined with gan-glioside in treating acute cerebral infarction. Methods: All 180 patients were randomly allocated to the observation group and the control group, 90 cases each group. Both groups accepted routine treatment, the observation group ac-ceptedKuDieZiinjection combined with ganglioside on the foundation of basic treatment, the control group received ganglioside. Adverse reaction, clinical effects, Barthel index, NIHSS scales and hematology changes of both groups were observed. Results: The observation group was superior to the control group in clinical effects, NIHSS scales, Barthel scales and hematology indexes, and the difference showed statistical meaning (P<0.05); no abnormal changes of clinical meaning and obvious adverse reaction has been found in both groups during therapeutic periods. Conclusion:KuDieZiinjection combined with ganglioside in treating acute cerebral infarction could effectively im-prove blood rheology and clinical effects of the patients effectively.