| SRI63—441对内毒素和血小板激活因子致肺损伤作用的影响 |
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| 引用本文： | 丁自强,李少华.SRI63—441对内毒素和血小板激活因子致肺损伤作用的影响[J].中国药理学通报,1990,6(3):168-170. |
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| 作者姓名： | 丁自强 李少华 |
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| 作者单位： | 第二军医大学病理生理教研室，第二军医大学病理生理教研室，第二军医大学病理生理教研室，第二军医大学病理生理教研室，第二军医大学病理生理教研室 上海 200433，上海 200433，上海 200433，上海 200433，上海 200433 |
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| 摘 要： | 大鼠颈外静脉注射内毒素和血小板激活因子(PAF)均可诱发严重肺水肿,肺血管外水量,肺泡灌洗液中蛋白浓度、细胞计数和多形核粒细胞分类均显著增高。PAF受体拮抗剂SRI63—441对内毒素和PAF所致肺水肿和肺泡灌洗液细胞学变化有部分改善作用。
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| 关 键 词： | 内毒素 血小板激活因子 受体拮抗剂 肺损伤 支气管肺泡灌洗 |
EFFECTS OF SRI63-441 ON ENDOTOXIN AND PAF INDUCED LUNG INJURY |
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| Ding Ziqiang,Li Shaohua,Fei Xia et al.EFFECTS OF SRI63-441 ON ENDOTOXIN AND PAF INDUCED LUNG INJURY[J].Chinese Pharmacological Bulletin,1990,6(3):168-170. |
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| Authors: | Ding Ziqiang Li Shaohua Fei Xia |
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| Abstract: | A bolus injection of endotoxin and platelet activating factor ( PAF ) via external jugular vein in rats resulted in severe pulmonary edema, accompanied by significant increase in extravascular lung water volume, bronchoalveolar lavage fluid ( BALF ) protein concentration, BALF cell counts and polymorphonuclearcyte percentage. PAF receptor antagonist SRI63-441 showed partial protective effects on endotoxin and PAF induced lung edema and BALF cytological changes. |
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| Keywords: | Endotoxin Platelet-activating factor Receptor antagonist Lung injury Bronchoalveolar lavage |
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