| GH-IGF-1轴与儿童生长发育 |
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| 引用本文： | 朱玉芳,潘革.GH-IGF-1轴与儿童生长发育[J].医学综述,2008,14(3):321-323. |
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| 作者姓名： | 朱玉芳 潘革 |
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| 作者单位： | 广西医科大学第三附属医院儿科,南宁,530021 |
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| 摘 要： | 生长激素-胰岛素样生长因子1(GH-IGF-1)轴是儿童生长发育的主要调控因素。GH、IGF-1有广泛的生理作用,可促进细胞增殖,直接或间接调节骨骼生长,调节机体生长发育和物质代谢。GH的促生长作用是由IGF-1介导的。GH-IGF-1轴功能受损,会导致生长发育落后。小于胎龄儿的生长落后可能与GH-IGF-1轴持续受损有关。慢性疾病导致生长发育落后与GH-IGF-1轴功能紊乱有关。
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| 关 键 词： | 生长激素 胰岛素样生长因子1 胰岛素样生长因子结合蛋白3 生长发育 |
| 文章编号： | 1006-2084（2008）03-0321-03 |
| 收稿时间： | 2007-08-11 |
| 修稿时间： | 2008-01-30 |
Growth Hormone-Insulin-like Growth Factor-1 Axis Collects And Children's Growth and Development |
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| ZHU Yu-fang,PAN Ge.Growth Hormone-Insulin-like Growth Factor-1 Axis Collects And Children''''s Growth and Development[J].Medical Recapitulate,2008,14(3):321-323. |
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| Authors: | ZHU Yu-fang PAN Ge |
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| Institution: | ZHU Yu-fang,PAN Ge.(Pediatric Department,the Third Affiliated Hospital of Guangxi Medical University,Nanning 531001,China) |
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| Abstract: | Growth hormone--Insulin-like growth factor- 1 （ GH-IGF- 1） axis is one of major regulation factors in children＇s growth and development. GH and IGF-1 have extensive physiological functions, which can promote cell proliferation and adjust organism development arid affect substance metabolism. Further- more they can directly or indirectly regulate skeleton growth. Growth-Promoting actions of GH were mediated by IGF-1. GH-IGF-1 axis damages will result in growth and developmental delay. Growth retardation of SGA probably may be related to continued damage GH-IGF-1 axis. Growth retardation due to chronic diseases were regarded to be associated with functional disorder of GH-IGF-1 axis. |
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| Keywords: | Growth hormone Insulin-like growth factor-1 Insulin-like growth factor binging protein-3 Growth and development |
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