新型声学造影方法评价兔肾脏VX2肿瘤血流灌注的实验研究

目的　探索新型声学造影技术在评价肾脏ＶＸ２ 肿瘤血流灌注方面的诊断价值。方法　５ 只患有ＶＸ２肾肿瘤的新西兰白兔经耳缘静脉注射ＦＸ５３０ 声学造影剂，用二次谐波和基波显像观察兔肾造影效果，分析使用视觉评分和视频密度定量。结果　新型声学造影方法显著地增强了肾肿瘤的超声影像、实时显示了肿瘤异常血流灌注状态，即呈“充盈缺损”状负性显影。ＶＸ２ 肿瘤与肾皮质的视频密度灰阶差值从造影前的１６６ 提高到４５８３（ 基波）和８０１７（ 二次谐波） 。结论　新型声学造影技术可以反映肾脏ＶＸ２ 肿瘤的异常血流灌注，显著提高肿瘤影像清晰度。

Assessment of Renal VX2 Cancer Perfusion Using New Contrast Ultrasonography

Objective The Values of new ultrasound contrast techniques were assessed in blood perfusion of renal VX2 cancer of rabbits.Methods 5 renal VX2 cancer bearing rabbits were imaged with fundamental and second harmonic imaging following intravenous injection of ultrasound contrast agent FX530. The subjective scores and video intensities of contrast imaging were analyzed. Results Contrast ultrasound showed realtime perfusion defect and delineation of VX2 tumors due to the abnormal blood perfusion. There were a significantly tumor/cortex intensity increases from 16.6(basline) to 45.83 in fundamental and 80.17 in harmonic ( P <0.01).Conclusion New ultrasound contrast imaging was of great value in assessing abnormal blood perfusion and improving delineation of renal VX2 cancer.