血管内皮生长因子在脑星形细胞瘤中的表达及其意义

目的　探讨血管内皮生长因子 (VEGF)在脑星形细胞瘤中的表达及其与肿瘤生长、预后和血管生成的关系。方法　应用免疫组化方法检测 82例脑星形细胞瘤瘤组织中VEGF表达、MVD ,并分析VEGF表达与血管生成、病理分级、临床预后等临床病理的关系。结果　VEGF表达与MVD呈正相关 (r=0 .6 3,P <0 .0 1)。星形细胞瘤病理级别越高 ,VEGF表达越强 (P <0 .0 5 ,0 .0 1)。瘤周水肿越重 ,VEGF表达也越强 (P <0 .0 5 ,0 .0 1)。VEGF表达与星形细胞瘤的大小、发生部位及男女性别无明显的相关关系 (P >0 .0 5 )。结论　星形细胞瘤的VEGF表达与其血管生成、预后及病理分级密切相关 ,可作为判断预后的独立指标。

Vascular endothelial growth factor expression and its significance in brain astrocytoma

Objective To study the relationship between the expression of vascular endothelial growth factor(VEGF) and the angiogenesis, growth and prognosis in brain astrocytoma.Methods Immunohistochemical techniques were used to detect the expression of VEGF and MVD in 82 cases of astrocytoma.The correlation of vascular endothelial growth factor(VEGF) expression with the angiogenesis, growth and prognostic value were analyzed.Results VEGF expression was correlated positively with MVD( r=0.63,P< 0.01): the more malignant the astrocytoma was, the higher the expression of VEGF( P <0.05,0.01). The VEGF expression was also correlated with peritumor edema( P <0.05,0.01), had not correlation with the size, the location of the tumor and the sex of patient( P >0.05).Conclusion The expression of VEGF has a significant correlation with the angiogenesis, growth and prognosis of brain astrocytoma and it may be an independent factor of prognosis of the disease.