Alzheimer’s and prion disease as disorders of protein conformation: implications for the design of novel therapeutic approaches |
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Authors: | C Soto |
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Institution: | (1) Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Santiago, Chile e-mail: sotojc01@popmail.med.nyu.edu Tel.: +56-2-6787244, Fax: +56-2-2713891, CL |
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Abstract: | Several lines of evidence suggest that a defective protein folding is a central event in both Alzheimer’s and prion disease.
Although the two disorders are very different clinically, neuropathologically, and biochemically, the molecular event that
may trigger the disease process appears to be the same: the formation of an altered protein conformer composed of a high content
of β-sheet structure. Compounds with the ability to prevent and to reverse protein conformational changes may be useful as
novel therapeutic approaches for Alzheimer’s disease, prion disease, and other disorders of defective protein folding.
Received: 28 December 1998 / Accepted: 8 February 1999 |
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Keywords: | Alzheimer’ s disease Spongiform encephalopathies Protein conformation Therapy β -Sheet breaker peptides |
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