Borna disease, a progressive meningoencephalomyelitis as a model for CD4+ T cell-mediated immunopathology in the brain |
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| Authors: | J A Richt L Stitz H Wekerle R Rott |
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| Affiliation: | Institut für Virologie, Justus-Liebig-Universit?t Giessen, Federal Republic of Germany. |
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| Abstract: | A homogeneous T cell line NM1 with Borna disease (BD) virus reactivity could be established. The NM1 cells have been characterized as CD4+ T cells. Adoptive transfer revealed that this MHC class II-restricted immune cell is responsible for the immunopathological effect leading to BD, a progressive meningoencephalomyelitis. |
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