血清绒毛膜促性腺激素、孕酮、泌乳素与早期妊娠结局的关系分析

目的 探讨绒毛膜促性腺激素(HCG)、孕酮(P)、泌乳素(PRL)与早期妊娠结局的关系.方法 以早期异常妊娠为甲组共30例,包括胚胎停育26例,异位妊娠4例;乙组为维持至中、晚期妊娠或分娩共80例.在停经≤40d、41～50d、51～60d、61～70d、71～80d不同时段每例测定3项值2～4次;定期B超检测妊娠情况.结果 停经≤40d孕酮值甲组明显低于乙组,停经41～50d和停经51～60d HCG和P值甲组明显低于乙组.各期PRL值两组间无统计学意义.回归分析:停经≤40d孕酮与妊娠结局相关(P＜0.05);停经41～50d孕酮与妊娠结局显著相关(P=0.000 6);停经41～50d绒毛膜促性腺激素和停经51～60d时孕酮、绒毛膜促性腺激素与早期妊娠结局相关(P＜0.05).结论 停经早期测定血清孕酮值确定早期异常妊娠较测定HCG值更有意义.血清泌乳素与早期自然流产的关系有待深入研究.

Study on association between serum human chorionic gonadotrophin,progesterone,prolactin and gestation outcome in early pregnancy

Objective To investigate the association between serum human chorionic gonadotrophin(HCG),progesterone(P),prolactin(PRL) and the gestation outcome in early pregnancy.Methods A total of 30 cases of abnormal early pregnancy were studied and 80 cases of normal pregnancy women as the control group.The study group included 26 patients of missed abortion and 4 patients of ectopic pregnancy.The values of serum HCG,P and PRL were measured during early pregnancy.B-mode ultrasonography monitioned the pregnancy outcome.Results During pregnancy 40d,the value of serum P in study group was significantly lower than that in control group.During pregnancy 41-50d and 51-60d,the values of serum HCG and P of study group were significantly lower than those in control group.The levels of serum PRL had no significant difference between two groups.The results of regressive analysis were as fallows:during pregnancy 40d,the positive correlation between P levels and gestation outcome existed(P<0.05);during pregnancy 41-50d,the positive correlation between P levels and gestation outcome existed(P=0.000 6);during pregnancy 41-50d and 51-60d,the positive correlation between P levels/ HCG levels and early gestation outcome existed(P<0.05).Conclusion Measuring the value of serum P is superior to the measurement of serum HGC for determing early abnormal pregnancy during early pregnancy.The relationship between serum PRL and early abortion remains to be determined.