运动神经元病患者肺功能改变的临床研究

目的探讨运动神经元病肺功能受损情况及病理生理原因.方法测定54例患者的肺功能并与正常对照组进行比较.结果患者通气功能明显减低(P＜0.01),以限制性通气障碍为主要损害占70%以上,小气道受损约占60%,弥散功能受损占48.14%.结论运动神经元病患者肺功能损害以限制性通气障碍为主.其肺功能损害的病理生理是由于支配呼吸肌的神经元进行性减少,呼吸肌出现失神经萎缩,呼吸肌无力而出现一系列肺功能改变.

Study of pulmonary function changes in patients with motor neuron disease

Objective] To explore the pathophysiological reasons for pulmonary function disturbance in patients with motor neuron diseases(MND).Methods] General pulmonary function of 54 MND patients was measured and the data were compared with that of the control group.Results] Test showed that the ventilation function was reduced remarkably with significant difference(P <0.01).74% of the patients showed restrictive ventilitory disorder,and 60% showed small airway function injuries,and 48.14% showed diffusion function injuries.Conclusions] The most characteristic pulmonary function change in MND is the restrictive ventilitory disorder.The pathophysiogical mechanism for pulmonary function disturbance is because of the following:the neuron which steers the respiratory muscles gradually decreasing;the respiratory muscles atrophy and respiratory muscles asthenia appearing;a series changes of pulmonary function occurred.