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| 银杏酸单体化合物的制备 | |
| 引用本文： | 仰榴青,吴向阳,陈钧.银杏酸单体化合物的制备[J].中国药学杂志,2003,38(12):909-911. |
| 作者姓名： | 仰榴青 吴向阳 陈钧 |
| 作者单位： | 1. 江苏大学药学院,江苏,镇江,212001 2. 江苏大学化学化工学院,江苏,镇江,212013 3. 江苏大学生物与环境工程学院,江苏,镇江,212013 |
| 基金项目： | 江苏省高校自然科学研究基金资助项目 ( 0 1KJD3 5 0 0 0 1) |
| 摘 要： | 目的研究银杏酸单体化合物的制备方法，为银杏酸的应用研究提供参考，为银杏提取物中银杏酸的定量分析提供单体对照品。方法银杏外种皮用石油醚回流提取，提取物通过硅胶柱色谱分离，得银杏酸混合物，再经制备柱反复分离，得银杏酸单体。结果石油醚回流提取法所得银杏酸得率为4.06%，纯度84.59%,提取率达62.9%。银杏酸混合物经制备色谱多次分离后，得到6种银杏酸单体，其中一种为新发现的化合物，纯度均达95%以上。结论单体制备方法较为简便，可用于高纯度银杏酸单体的制备。 |
| 关 键 词： | 银杏外种皮 银杏酸 单体 高效液相色谱法 |
| 文章编号： | 1001-2494(2003)12-0909-03 |
| 收稿时间： | 2002-11-11; |
| 修稿时间： | 2002年11月11 |
Study on preparation of ginkgolic acids monomers |
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| YANG Liu-qing ,WU Xiang-yang ,CHEN Jun.Study on preparation of ginkgolic acids monomers[J].Chinese Pharmaceutical Journal,2003,38(12):909-911. | |
| Authors: | YANG Liu-qing WU Xiang-yang CHEN Jun |
| Institution: | YANG Liu-qing 1,WU Xiang-yang 2,CHEN Jun 3 |
| Abstract: | OBJECTIVETo study the preparation of ginkgolic a ci d(GA) monomers from sarcotestas of Ginkgo biloba for applied research and qu antitative analysis of GA.METHODSGA were extracted by petro leum ether reflux extraction from sarcotestas of Ginkgo biloba.The extracts were separated by silica gel column and the mixture of GA was obtained.Then the GA mixture was isolated by preparation chromatography repeatedly and monomers we re obtained.RESULTSThe yield,purity and extraction ratio of GA by petroleum ether reflux extraction were 4.06%,84.59% and 62.9%,respectivel y.Six monomers were obtained,one of them was a new compound.The purity of the mo nomers reached 95% or higher.CONCLUSIONThe method for prepa ration of GA monomers was simple,and may be used in preparation of high purity m onomers. |
| Keywords: | sarcotestas of Ginkgo biloba ginkgolic acids m onomers HPLC |
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