栓塞后动脉瘤病理分析

目的：观察弹簧圈栓塞后动脉瘤瘤腔内血栓形成和瘤口内皮细胞生长封闭瘤口情况。方法：本实验用静脉袋移植法制作兔分叉型动脉瘤模型，用电解可脱式弹簧圈栓塞（GDC）进行栓塞，然后在电镜下分别观察24h,3日，3月后标本。结果：24h组标本在栓塞达到次全栓塞时瘤腔内即有血栓形成，3日组标本显示腔内血凝块发生机化，3月组标本显示完全栓塞的动脉瘤的动脉瘤口有完整的内皮细胞膜，而次全栓塞的动脉瘤口只有部分内皮细胞膜。结论：弹簧圈栓塞动脉瘤时致密栓塞动脉瘤对于诱发形成横过瘤口的完整内皮细胞膜，防止动脉瘤复发十分重要。

The Pathological Analysis of The Embolized Aneurysms

Objective:To present a detail of the experiment to observe the thrombogentic characteristics in the cavities of aneurysms models and a layer of endothelium on the ariface.Menthod:Forteen bifurcation aneurysm models in chinese rabbits by venous pouchs transplanting were made,Then these are occluded by GDC throungh endovascular way.From one day to three months after embolization,rabbits were sacrified and used for the periodically angiographical observation.Results:The cavitives of aneurysm models were occluded by coils and granulation tissue in subtotal occlusion and complete occlusion aneurysms one day after embolization.Two complete layers of endothelium were seen at the arifaces of two complete occlusion aneurysms.The incomplete layers of endothelium was seen at the arifaces of the incomplete occlusion aneurysms three months after embolization.Conclusion:Dense packing of aneurysms is very important to endothelium at the arifaces of aneurysms and the prevention of rehamorrage of aneurysms