地诺前列酮栓用于足月妊娠引产的临床评价

目的评价地诺前列酮阴道栓剂用于足月妊娠引产的有效性和安全性。方法对本院2008年1月至10月间足月妊娠应用地诺前列酮栓引产的320例病例进行回顾性分析,设为观察组;另外随机选择同期足月妊娠自然临产孕妇320例为对照组,比较两组产程、妊娠结局。结果观察组中放置地诺前列酮栓后直接临产者268例(83.75%),需静脉滴注缩宫素临产者33例(10.31%),引产失败者19例(5.94%)。观察组第一、二产程均缩短,(P<0.01,P<0.05)。缩宫素使用率、剖宫产率观察组明显小于对照组(P<0.01)。两组的胎儿窘迫、新生儿窒息、产后出血发生率比较差异无统计学意义(P>0.05)。结论地诺前列酮栓用于足月妊娠引产安全、有效。在使用中应注意放药指征和撤药时机,以保证安全性和成功率。

Clinical Evaluation of Dinoprostone Pessary for Labor Induction in term Pregnancy

Objective To evaluate the efficacy and safety of dinoprostone pessaryi iin intermediate labor induction. Methods Retrospective analysis 320 cases in our hospital between Jan. to Oct .2008 who were term pregnancy and were placed with dinoprostone pessary to induce labor. The other 320 cases of women of labor spontaneous in the same condition was considered as control group.The labor and pregnancy outcome were compared between the two groups. Results In the study group,after using dinoprostone pessary, the pregnant women of labor were 268 （83.75%） ,the number of labor with the help of intravenous oxytocin were 33（10.31%）and the number of unsuccessfully induced labor were 19（5.94%）. The fast and second stage was abbreviated in the study group （P〈0.01, P〈0.05）. The rate of oxytocin usage and cesarean section in the study group is lower than in the control group（P〈0.01）.No statistical difference were observed in the rate of fetal distress, neonatal asphyxia and postpartum hemorrhage between the tweo groups （P〉0. 05）. Conclusion Dinoprostone pessary is safe and effective for labor induction in term pregnancy.We should pay attention to its indication and the opportunity of withdrawal to ensure safety and achievement ratio.