| 自身抗体检测在儿童自身免疫性疾病中的意义 |
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| 引用本文： | 章迁,王晓川,王静漪,俞晔珩.自身抗体检测在儿童自身免疫性疾病中的意义[J].实用儿科临床杂志,2006,21(21):1470-1471,1493. |
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| 作者姓名： | 章迁 王晓川 王静漪 俞晔珩 |
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| 作者单位： | 复旦大学附属儿科医院,免疫室,上海,200032 |
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| 摘 要： | 目的 研究抗核抗体（ANA）、ANA荧光分型、抗可溶性抗原（ENA）抗体和抗双链DNA（ds-DNA）抗体检测在儿童自身免疫性疾病中的意义。方法 对住院患儿中ANA、抗ENA，或抗ds-DNA抗体至少1项阳性者共135例进行总结，分别计算其阳性预测值（PV）。结果 ANA阳性中自身免疫性疾病的PV=0．36，ANA荧光强度与PV成正比，ANA荧光分型中细颗粒型对于SLE有较高的PV；抗ENA抗体和抗ds-DNA抗体对自身免疫性疾病PV高于ANA。结论 ANA荧光强度，抗ENA抗体和抗ds-DNA抗体阳性对自身免疫性疾病有较高的诊断价值。
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| 关 键 词： | 抗体 抗核 抗可溶性抗原抗体 抗双链DNA抗体 自身抗体 |
| 文章编号： | 1003-515X（2006）21-1470-02 |
| 收稿时间： | 2006-09-01 |
| 修稿时间： | 2006-09-01 |
Effect of Autoantibody Tests in Diagnosis of Autoimmune Diseases in Children |
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| ZHANG Qian,WANG Xiao-chuan,WANG Jing-yi,YU Ye-heng.Effect of Autoantibody Tests in Diagnosis of Autoimmune Diseases in Children[J].Journal of Applied Clinical Pediatrics,2006,21(21):1470-1471,1493. |
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| Authors: | ZHANG Qian WANG Xiao-chuan WANG Jing-yi YU Ye-heng |
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| Abstract: | Objective To study the effect of autoantibody test which includes antinuclear antibodies(ANA),antinuclear antibody fluorescence patterns,anti-extractable nuclear antigen(ENA) antibodies and anti-double strands DNA(ds-DNA) antibodies in the diagnosis of pediactic autoimmune diseases.Methods Of all the inpatients which had positive results of autoantibody tests,135 cases were reviewed.The autoantibody assay,positive value(PV) analysis were performed respectively.Results PV of ANA test to autoimmune diseases was 0.36 which was proportional to the intensity of fluorescence;Of all the fluorescence patterns,speckled(fine) had a relatively high PV;Anti-ENA and anti-dsDNA antibody tests had higher PV than ANA test.Conclusion Fluorescence intensity,(anti-ENA) antibody test and anti-dsDNA antibody test may be useful in identifying autoimmune diseases in clinic. |
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| Keywords: | antibodys antinuclear anti- extractable nuclear antigen antibody anti - double strands DNA antibody autoantibody |
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