| 血管内皮生长因子和第VIII因子相关抗原在脑出血大鼠脑内的表达 |
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| 引用本文： | 揣兰香,张微微,戴卫平. 血管内皮生长因子和第VIII因子相关抗原在脑出血大鼠脑内的表达[J]. 中国组织工程研究与临床康复, 2003, 7(7): 1186-1186 |
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| 作者姓名： | 揣兰香 张微微 戴卫平 |
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| 作者单位： | Department of Retired Cadres，254th Hospital of PLA，Tianjin 300142，Hebei Provin ce，China，Department of Neurology，General Ho spital of Beijing Mili-tary Region，Beijing 100700，China，Department of Retired Cadres，254th Hospital of PLA，Tianjin 300142，Hebei Provin ce，China |
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| 摘 要： | INTRODUCTIONTostudyfurthertheeffectofvascularendothelialgrowthfasto（VEGF）onbrainhemorrhage，thisstudyadoptedratofmodelofICHandtherelationshipbetweentheexpressionofVEGFandthebrainangionesisafterintracerebralhemorrhagewasobservedandtheeffecoftheexpressionofVEGFonsecondbraininjuryafterbrainhem－orrhage．MATERIALSANDMETHODSMaterials３６healthyandadultSDratsweightedfrom２５０to２８０genteredthistudy，whichwasprovidedbyexperimentalanimalscenterofGeneraHospitalofPLA．Theratswer…
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| 修稿时间： | 2002-11-02 |
The expression of vascular endothelial growth factor and Factor VIII related antigen in the border zone after intracerebral hemorrhage in rats |
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| Chuai Lanxiang,Dai Weiping. The expression of vascular endothelial growth factor and Factor VIII related antigen in the border zone after intracerebral hemorrhage in rats[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2003, 7(7): 1186-1186 |
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| Authors: | Chuai Lanxiang Dai Weiping |
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| Affiliation: | 1. Department of Retired Cadres,254th Hospital of PLA,Tianjin 300142,Hebei Province,China
2. Department of Neurology,General Hospital of Beijing Military Region,Beijing 100700,China |
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| Abstract: | AIM:To observe the expression of vascula r endothelial growth factor(VEGF)and Factor VIII related antigen(FVIII-R Ag )in rats brain tissue in the bor-der zone of the hematoma,and explore the relationship between the expres-sion of VEGF and the brain angionesis after intracerebral hmorrhage(ICH).METHODS:Rat of model of ICH was induced by inje ction of collagenase physiological saline into the right caudate nucleus.The immunohistoch emical methods were performed by using diff erent antisera of VEGF and FVIII-R Ag in serial sections of rats brain at 12h,1d,3d and 7d after ICH respec-tively.RESULTS:T he amount of VEGF positive cells was markedly in-creased,and reached the highest at 7th day in the border zone after ICG(P<0.01),but there were no significant diffe rence among the mean value of A of cells at different time points(P>0.05).Compared with the controls,both the FVIII-R Ag positive endothelial cells and the A of cells were signific antly different in experimental ICH goups after 1day.CONCLUSION:The up-regulated expression of VEGF might i nduce proliferation of endothelial cell and angiogenesis in the border zone a fter ICH in rats. |
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| Keywords: | cerebrovascular accident endothelial growth factor fator VIII rats |
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