肺癌患者红细胞免疫功能与外周血T淋巴细胞亚群的改变及其临床意义

目的：观察肺癌患红细胞免疫功能及T淋巴细胞亚群的变化。方法：检测55例肺癌患进行红细胞免疫功能及T淋巴细胞亚群检测,并与15例肺良性肿瘤患和20例正常人对照。结果：（1）肺癌组红细胞C3b受体花环率（RBC－C3b recepfor rosette,RR)，CD3＋，CD4＋，CD8＋，CD4＋／CD8＋比值低于正常人（P＜0．05），红细胞免疫复合物花环率（RBC－1CR）依次高于肺良性肿瘤组，正常人（P＜0．05），（2）Ⅲa,Ⅲb期肺癌，RBC－1CR高于正常人（P＜0．01），I，II期病人CD3＋，CD4＋，CD8＋低于正常人（P＜0．01），RBC－1CR高于正常人（P＜0．01），结论：肺癌患RBC免疫和T细胞亚群的测定，对肺癌的诊断，治疗及病情预后估计有一定价值。

Changes of erythrocytic immune function and T lymphocyte subsets of peripheral blood in patients with lung cancer and then clinical significance

Objective: To study the changes of erythrocytic immune function and T lymphocyte subsets in lung cancer patients. Methods: Erythrocyte immune functions and T lymphocyte subsets were detected in 55 cases of lung cancer; 15 cases of lung benign neoplasm and 20 healthy persons were chosen as control. Results: (1) RRC- C3bRR, CD3+, CD4+, CD8+, CD4+/CD8+ ratio of lung cancer patients were significantly lower than those of healthy group (P ＜ 0.05); however RBC - 1CR of lung cancer patients were significantly higher than those of lung benign neoplasm and healthy group (P＜0.05) in turn. (2) RBC-C3bRR, CD3+ , CD4+ , CD4+/CD8+ ratio of Ⅲa, Ⅲb staged lung cancer patients were significantly lower than those of Ⅰ , Ⅱ stages and healthy group ( P ＜ 0.05);RBC-1CR of Ⅲa, Ⅲb stage in lung cancer patients was significantly higher than those of healthy group (P＜0.01), CD3+,CD4+, CD8+ of stage Ⅰ , Ⅱ patients were significantly lower than those of healthy group (P＜0.01 ), and RBC - 1CR of stage Ⅰ , Ⅱ patlents was significantly higher (P＜0.01). Conclusion: Detection of erythrocyte immune functions and T lymphocyte subsets may be useful in the diagnosis, treatment and prognos is of lung cancer.