| Characteristic of hyaluronic acid derivative films cross-linked by polyethylene glycol of low water content |
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| 作者单位： | Chen Jinghua（College of Publishing and Printing, University of Shanghai for Science and Technology, Shanghai 200093, China;College of Materials Science and Technology, Tongfi University, Shanghai 200092, China） ;Chen Jingtao（College of Materials Science and Technology, Tongfi University, Shanghai 200092, China） ;Xu Zheng（College of Materials Science and Technology, Tongfi University, Shanghai 200092, China） ;Gu Qisheng（The Institute of Qisheng Biomaterial Technology, Shanghai 201106, China） ; |
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| 摘 要： | Objective： To test the characteristics of hyaluronic acid （HA） derivative cross-linked by polyethylene glycol films of low water content. Methods： The cross-linked HA film with 200 μm thickness was got at atmospheric pressure at 25℃ for 5 d. After dried, cross-linked films of 10 mm×10 mm were weighed and immersed in phosphate buffered saline （PBS pH 7.45） at 37℃ for 24 h. Then the solution fraction and water content were estimated. Meanwhile, cross-linked HA derivative films were immersed in phosphate buffered saline （PBS： pH 7.45） at 37℃ for determined time and then implanted subcutaneously in the back of white rats to test in vitro or in vivo degradation characteristic. Results and Conclusion： HA hydrogel cross-linked by polyethylene glycol with water content is as low as 60% and this kind of HA derivative has a slow degradation rate.
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| 关 键 词： | 聚乙烯乙二醇 老化速度 水含量 体液 |
| 收稿时间： | 2006-05-25 |
| 修稿时间： | 2007-10-18 |
Characteristic of hyaluronic acid derivative films cross-linked by polyethylene glycol of low water content |
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| Chen Jinghua,Chen Jingtao,Xu Zheng,Gu Qisheng. Characteristic of hyaluronic acid derivative films cross-linked by polyethylene glycol of low water content[J]. Journal of Medical Colleges of PLA(China), 2008, 23(1): 15-19. DOI: 10.1016/S1000-1948(08)60003-9 |
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| Authors: | Chen Jinghua Chen Jingtao Xu Zheng Gu Qisheng |
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| Affiliation: | [1]College of Publishing and Printing, University of Shanghai for Science and Technology, Shanghai 200093, China; [2]College of Materials Science and Technology, Tongji University, Shanghai 200092, China; [3]The Institute of Qisheng Biomaterial Technology, Shanghai 201106, China |
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| Abstract: | Objective: To test the characteristics of byaluronic acid (HA) derivative cross-linked by polyethylene glycol films of low water content. Methods: The cross-linked HA film with 200 μm thickness was got at atmospheric pressure at 25℃ for 5 d. After dried, cross-linked films of 10 mm×10 mm were weighed and immersed in phosphate buffered saline (PBS pH 7.45) at 37℃ for 24 h. Then the solution fraction and water content were estimated. Meanwhile, cross-linked HA derivative films were immersed in phosphate buffered saline (PBS: pH 7.45) at 37℃ for determined time and then implanted subcutaneously in the back of white rats to test in vitro or in vivo degradation characteristic. Results and Conclusion: HA hydrogel cross-linked by polyethylene glycol with water content is as low as 60% and this kind of HA derivative has a slow degradation rate. |
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| Keywords: | hyaluronic acid polyethylene glycol water content degradation rate |
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