| 抗人喉癌/抗CD3双功能抗体的制备及对Hep-2细胞株的杀伤作用 |
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| 引用本文： | 冯青杰,闫世军,孙立群,吴东辉.抗人喉癌/抗CD3双功能抗体的制备及对Hep-2细胞株的杀伤作用[J].中国免疫学杂志,2003,19(5):359-360. |
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| 作者姓名： | 冯青杰 闫世军 孙立群 吴东辉 |
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| 作者单位： | 吉林大学第二医院,长春,130041 |
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| 摘 要： | 目的：研究制备抗人喉癌／抗CD3双功能抗体，探讨喉癌主动免疫治疗。方法：以化学方法将人喉癌及抗CD3单克隆抗体交联为双功能抗体，进行介导对肿瘤细胞的杀伤作用。结果：该双功能抗体介导效应细胞对靶细胞的杀伤率高于抗CD3的介导作用，并随着效靶比的提高而升高。结论：采用化学交联法制备的抗人喉癌／CD3双功能抗体具有潜在的临床应用价值。
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| 关 键 词： | 喉癌 抗CD3 双功能抗体 制备 Hep－2细胞株 杀伤作用 |
| 文章编号： | 1000-484X(2003)05-0359-02 |
The preparation and the killer function on Hep-2 clone of bifunction antibody of anti-human laryngocarcinoma/anti-CD3 |
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| FENG Qing-Jie,YAN Shi-Jun,SUN Li-Qun et al.Second Clinical College of Jilin University,Changchun ,China.The preparation and the killer function on Hep-2 clone of bifunction antibody of anti-human laryngocarcinoma/anti-CD3[J].Chinese Journal of Immunology,2003,19(5):359-360. |
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| Authors: | FENG Qing-Jie YAN Shi-Jun SUN Li-Qun Second Clinical College of Jilin University Changchun China[ |
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| Institution: | FENG Qing-Jie,YAN Shi-Jun,SUN Li-Qun et al.Second Clinical College of Jilin University,Changchun 130041,China[ |
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| Abstract: | Objective:To prepare bifunction antibody of anti-human laryngocarcinoma/anti-CD 3 for the active immune therapy of laryngocarcinoma.Methods:To corss link monoclonal antibody of anti-human laryngocarcinoma and anti-CD 3 into bifunction antibody by chemical method,which can guide the killer function on carcinoma cells.Results:The killer rate of effector cells guided by bifunction antibody is higher than that of anti-CD 3 which can arise with the elevation of effect target ratio.Conclusion:Bifunction antibody of anti-human laryngocarcinoma/anti-CD 3 prepared by chemical cross linking method has the potential value for clinical application. |
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| Keywords: | Laryngocarcinoma Anti-CD 3 Bifunction antibody |
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