Severe Preeclampsia Associated with Coinheritance of Factor V Leiden Mutation and Protein S Deficiency |
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| Institution: | 1. Dairy Science and Technology, FQD, Wageningen University, Postbox 8129, 6700EV Wageningen, The Netherlands;2. Laboratory of Biochemistry, Wageningen University, The Netherlands;3. Gelderse Vallei Hospital, Ede, The Netherlands;1. Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, via Orabona 4, 70125 Bari, Italy;2. Center of Excellence in Comparative Genomics, University of Bari, via Orabona 4, 70125 Bari, Italy;3. CNR Institute of Biomembranes and Bioenergetics, Bari, Italy;4. Department of Science, University of Basilicata, 85100 Potenza, Italy;5. Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Naples, Italy |
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| Abstract: | Background: Inherited thrombophilic disorders are associated with an increased risk of venous thromboembolism during pregnancy. Preliminary research suggests that these disorders might also increase the risk for preeclampsia.Case: A 29-year-old primigravida developed severe, early onset preeclampsia and postpartum deep venous thrombosis. Subsequent testing revealed coinheritance of the factor V Leiden mutation and protein S deficiency. Heparin prophylaxis was administered during two subsequent pregnancies without recurrence of either preeclampsia or venous thromboembolism.Conclusion: Our patient’s inherited thrombophilia may have played a role in the development of preeclampsia, and anticoagulation during subsequent pregnancies may have prevented preeclampsia recurrence. An association between inherited thrombophilic disorders and preeclampsia is biologically plausible. |
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