Use of induced sputum to examine airway inflammation in childhood asthma |
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| Affiliation: | 1. School of Nursing, Beijing University of Chinese Medicine, Beijing, 11 Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China;2. Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine; 11 Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China;3. Department of General Practice, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15/1. Stock, A-1090, Vienna, Austria;4. National Research Centre in Complementary and Alternative Medicine (NAFKAM), Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway;1. Laboratoire National de métrologie et d’Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France;2. UMR CNRS 8038 CiTCoM, Chimie-Toxicologie Analytique et Cellulaire, Université de Paris, Faculté de Pharmacie de Paris, 4 avenue de l’Observatoire, 75006 Paris, France;3. Hôpital Européen Georges Pompidou, AP-HP, Service de Biochimie, 24 rue Leblanc, 75015 Paris, France;1. Department of Biomedical Engineering and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA;2. Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA;3. Departments of Materials Science and Engineering and Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA;4. Departments of Oncology, Ophthalmology, and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA;5. Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA;1. Faculty of Agriculture and Life Sciences, Lincoln University, Lincoln, 7647, Christchurch, New Zealand;2. AgResearch Limited, Invermay Agricultural Centre, Puddle Alley, Mosgiel, New Zealand;3. AgroSup Dijon, 21000, Dijon, France |
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| Abstract: | Airway inflammation is important in the pathogenesis of asthma, during which it may lead to symptomatic exacerbations and increases in asthma severity, as well as contribute to future decline in asthma status. The use of induced sputum has emerged as an important and useful technique to study airway inflammation. It has particular advantages in the study of childhood asthma because it is noninvasive and allows samples to be collected on repeated occasions in children over 7 years of age. The results of cell counts are reliable when the sputum is processed in a standardized manner involving selection from saliva, cell dispersion, and quantitative cytology. Children with asthma have increased eosinophils and mast cells, which may persist even with high doses of inhaled corticosteroid therapy. During a severe exacerbation of asthma, there is an intense and heterogeneous inflammatory response involving eosinophil and neutrophil accumulation and activation. Characterization of the relevance of airway inflammation in children with asthma is important. (J Allergy Clin Immunol 1998;102:S100-1.) |
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