Substantia nigra lesion suppresses the antagonistic effects of N-methyl-d-aspartate receptor antagonist (MK-801) on the autotomy in the rat |
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| Institution: | 1. Department ofNuclear Medicine, China;2. Department of Oral and Craniomaxillofacial Science, Ninth People''s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;1. Department of Rheumatology and Immunology, The First Affiliated Hospital of Bengbu Medical College, 287 Changhuai Road, Bengbu, Anhui, 233004, China;2. Anhui Province Key Laboratory of Immunology in Chronic Diseases, 2600 Donghai Avenue, Bengbu, Anhui, 233030, China;3. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China;4. Experimental Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China;5. Department of Radiology, The First Affiliated Hospital of Bengbu Medical College, 287 Changhuai Road, Bengbu, Anhui, 233004, China |
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| Abstract: | Rats received right dorsal root ganglionectomy (DRGn) to induce autotomy, and were treated with MK-801 and/or left stantia nigra (SN) lesion after DRGn. The behavior was quantified using an autotomy grading scale. All the rats in the control groups manifested autotomy from 4 to 19 days after DRGn and attained the highest autotomy score. The group treated with MK-801 immediately after DRGn showed suppression of the development of autotomy. The groups receiving left SN lesion with 6-hydroxydopamine immediately, 2, or 4 days after DRGn showed similar patterns of autotomy as the control groups. However, when combined with the administration of MK-801 immediately after DRGn, SN lesion done immediately or 2 days after DRGn suppressed the antagonistic effect of MK-801 (P<0.01). When the SN lesion was delayed by 4 days, the suppression effect disappeared. These data suggest that the action of the NMDA receptor antagonist on the autotomy within 4 days after DRGn depend on the integrity of the dopaminergic system. |
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