The peptide-binding strategy of the MHC class II I-A molecules |
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| Affiliation: | 1. Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada;2. Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada;3. Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;4. Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;5. Stem Cells, Canadian Blood Services, Ottawa, Ontario, Canada;6. Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada |
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| Abstract: | Despite the importance of murine major histocompatibility complex (MHC) class II I-A molecules for immunological research, the overall peptide-binding specificities of I-A and the homologous human HLA-DQ molecules remain unresolved. Here, Boris Reizis and colleagues review current evidence suggesting that DQ/I-A molecules bind peptides with a different hierarchy of anchor positions than has been found in the well-characterized DR/I-E proteins. |
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