Single administration of enterococcal preparation (FK-23) augments non-specific immune responses in healthy dogs |
| |
| Affiliation: | 1. School of Medical Sciences and Griffith Health Research Institute, Griffith University, Gold Coast campus, Southport, Queensland 4222, Australia;2. 98 Alive Pty Ltd., PO Box 82, Underwood, QLD 4119, Australia;3. National Defense Medical Center, Taipei, Taiwan;1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China;2. School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China;3. Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, Jiangsu 214122, China;4. International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, Jiangsu 214122, China |
| |
| Abstract: | Influence of a single administration of heat-killed Enterococcus faecalis FK-23 preparation (FK-23) on non-specific immune responses was evaluated in healthy dogs. The dogs received a single administration of FK-23 at a dose of 100 mg/kg perorally and thereafter a complete blood count (CBC) , leukocyte differential count, phagocytic activity of peripheral blood neutrophils and a lymphocyte blast transformation (LBT) test were assessed. Although FK-23 had no effect on the CBC or leukocyte differential count, treatment of the drug caused a 1.4-fold increase in neutrophil phagocytosis compared to FK-23 non-treated healthy dogs. LBT activities of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) were also activated to twice the control levels and that of concanavalin A (Con A) was increased to one and a half times by the FK-23 treatment. Thus, a single administration of FK-23 appears to augment host resistance through stimulation of the non-specific immune responses in vivo. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
