Forty-five year's experience of the treatment of choriocarcinoma and invasive mole |
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| Affiliation: | 1. University of Cincinnati Department of Obstetrics & Gynecology, 231 Albert Sabin Way MSB 4408, Cincinnati, OH 45267, USA;2. University of Cincinnati Department of Obstetrics & Gynecology: Division of Gynecologic Oncology, 234 Goodman Street, Cincinnati, OH 45219, USA;1. School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, People’s Republic of China;2. Beijing Key Laboratory for Sensors, Beijing Information Science & Technology University, Beijing 100192, People’s Republic of China;1. Rio de Janeiro Trophoblastic Disease Center (Maternity School of Rio de Janeiro Federal University and Antonio Pedro University Hospital of Fluminense Federal University), Brazil;2. Postgraduate Program in Perinatal Health, Faculty of Medicine, Rio de Janeiro, RJ, Brazil;3. Postgraduate Program in Medical Sciences, Fluminense Federal University, Niterói, RJ, Brazil;4. New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA, USA |
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| Abstract: | Our work was begun in 1949, through many yera's effort, several chemicals (such as 6 MP, 5 FU and others) were found to be effective for the treatment of choriocarcinoma (C.C.) and invasive mole (I.M.). From 1959 through 1985, 1500 patients were consecutively treated. The mortality rate of CC was reduced from > 90% to < 20%. No more death occurred in IM. All Survivors followed up for 10–38 years showed no evidence of residual disease. 80% of the young patients treated with chemotherapy alone conceived after recovery. The pregnancy outcome showed no deviation from that of the general population. All children are growing up normally many married and gave birth to normal third generations. The results indicated that chemotherapy with 5 FU achieves not only a complete remission, but also a cure, even with wide-spread metastases. The results of choriocarinoma and invasive mole treated with mainly 5 FU were reported. The clinical experience in the management of metastases at different sites were also summarized. |
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