Abolition of anaphylactic shock by solanum lyratum Thunb |
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| Affiliation: | 1. Aix Marseille Univ, UMR-MD3, Laboratory of Pharmacognosy and Ethnopharmacology, Faculty of Pharmacy, 27 bld Jean Moulin, CS 30064, 13385 Marseille, France;2. Aix Marseille Univ, Spectropole, FR1739, Service 511, Campus Saint-Jérome, 13397 Marseille, France.;3. Aix Marseille Univ, Laboratoire de Mutagenèse Environnementale, IMBE, IFR ECCOREV, Faculty of Pharmacy, 27 bld Jean Moulin, CS 30064, 13385 Marseille, France;4. Luberon Natural Regional Park, 60, place Jean Jaurès, 84400 Apt, France;5. Avignon University, Qualisud, UMR 95, F-84000 Avignon, France |
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| Abstract: | We investigated the effects of the aqueous extract of Solanum lyratum Thunb. (Solanaceae) (SLAE) on the anaphylactic reactions. SLAE inhibited compound 48/80-induced anaphylactic shock 100% with a dose of 1.0 mg/g body weight (BW) . When SLAE was pretreated at concentration ranging from 0.0001–1.0 mg/g BW, the serum histamine levels were reduced in a dose-dependent manner. Passive cutaneous anaphylaxis also inhibited to 69.3% by oral administration of SLAE (0.05 mg/g BW) . Moreover, SLAE dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when SLAE was added, significantly increased compared with that of normal control. These results indicate that SLAE possess strong antianaphylactic activity. |
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