Noninvasive Determination of Endothelial Cell Function in the Microcirculation in Kawasaki Syndrome |
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Authors: | Gregory H Kurio Katrine A Zhiroff Lily J Jih Arnost S Fronek Jane C Burns |
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Institution: | (1) Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093, USA;(2) Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093, USA;(3) Rady Children’s Hospital San Diego, San Diego, CA 92123, USA;(4) Present address: Division of Cardiology Children’s Hospital and Research Center at Oakland, 747 52nd Street, Oakland, CA 94609, USA |
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Abstract: | The aim of the study was to noninvasively assess endothelial cell (EC) function in the microcirculation using laser Doppler
fluximetry (LDF) in acute and convalescent Kawasaki syndrome (KS) patients and healthy controls. KS is an acute, self-limited
vasculitis of childhood that affects the EC of medium-sized arteries. No studies have addressed EC function in the peripheral
microcirculation. LDF preacetylcholine and postacetylcholine (ACh) iontophoresis estimates microcirculation EC nitric oxide
production leading to smooth muscle relaxation and vasodilatation, which are blunted in EC dysfunction. We studied a total
of 97 subjects: 36 acute and 27 convalescent KS patients and 34 normal children. Change in blood flow was measured by LDF
for 10 min post-ACh iontophoresis. Acute KS patients had significantly lower average flux when compared to convalescent KS
patients and controls in the first 5 min postiontophoresis. However, there was no difference in flux or area under the curve
(AUC) between convalescent KS patients and healthy controls. Despite a reduced response of the microvascular EC to ACh in
acute KS patients, convalescent patients with and without coronary aneurysms had microvascular EC function similar to normal
controls. This suggests that the EC injury in KS is confined to the endothelium of medium-sized arteries and that microvascular
EC function is normal after acute KS. |
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Keywords: | Coronary artery aneurysm Vasculitis Pediatric heart disease |
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