小柴胡汤对高脂血症性模型大鼠的作用观察

目的]探察小柴胡汤的降脂及抗脂肪肝形成的作用。方法]SD大鼠连续给予脂肪乳剂灌胃造模后分成模型组、小柴胡汤小、大剂量组、辛伐他汀组,各组继续给予脂肪乳剂灌胃,其中小柴胡汤小、大剂量组予小柴胡汤中药灌胃,辛伐他丁组给予辛伐他丁溶液灌胃,观测各组大鼠血脂、肝重及肝HE的变化。结果]模型组大鼠给予脂肪乳剂灌胃1w后,血脂较正常组显著升高(P0.01或P0.05),3w后血脂持续升高、肝脏指数增加及出现脂肪变。与模型组比较,各给药组大鼠血脂、肝脏指数及肝脂肪变程度均呈不同程度的降低,其中小柴胡汤大剂量组和辛伐他汀组的作用较明显。结论]小柴胡汤具有一定的降脂及抗肝脂肪变的作用。

Observation of Small Bupleurum Decoction on Model Rats with Hyperlipemia

Objective] To explore the function of Small Bupleurum Decoction on reducing lipid and anti fat liver.Method] After successively making stomach perfusion of fat emulsion to make SD rats model,then randomly divide into model group,Small Bupleurum Decoction small-dosage,big-dosage groups and Simvastatin group;successively make corresponding perfusion;observe their lipid,liver weight and HE change.Result] After 1w,in model group,the lipid is much more than before,after 3w,it rises continuously,so is liver in...