| 栀子总环烯醚萜苷对大鼠脑出血AQP4和MMP-2/9表达的影响 |
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| 引用本文： | 杨奎,戴扬,邬春久,向靓,黄薇,陈科,毛旭华,张明洪. 栀子总环烯醚萜苷对大鼠脑出血AQP4和MMP-2/9表达的影响[J]. 中药药理与临床, 2010, 0(2) |
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| 作者姓名： | 杨奎 戴扬 邬春久 向靓 黄薇 陈科 毛旭华 张明洪 |
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| 作者单位： | 成都中医药大学;成都百康医药工业药理毒理研究院; |
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| 基金项目： | 科技部十五攻关西部重点项目(2001BA901A45) |
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| 摘 要： | 目的:探讨栀子总环烯醚萜苷对大鼠脑出血AQP4和MMP-2/9表达的影响。方法:SD大鼠随机分为假手术组、模型组和栀子总环烯醚萜苷(30mg/kg)治疗组,采用自体血注入诱发大鼠脑出血模型,术后24、48、72和120h时间点各组各取5只大鼠脑组织标本,采用干湿重法、免疫组织化学染色、逆转录聚合酶链反应技术分别测定脑含水量、AQP4蛋白和AQP4mRNA的表达、MMP-2和MMP-9表达。结果:与模型组比较,治疗组大鼠在各时间点脑含水量减少(P0.01),AQP4蛋白和AQP4mRNA表达降低(P0.05),术后72～120h时间点MMP-2和MMP-9表达水平低(P0.05～P0.01)。结论:栀子总环烯醚萜苷可能通过抑制AQP4、MMP-2和MMP-9的表达减轻脑出血后脑水肿的形成。
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| 关 键 词： | 栀子总环烯醚萜苷 脑出血 水通道蛋白-4 基质金属蛋白酶2/9 |
Effects of total iridoid glycosides in Gardenia jasminoides on the expression of AQP4 and MMP-2/9 in perihematomal brain regions of rats |
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| Yang Kui,,Dai Yang,Wu Chunjiu,Xiang Liang,Huang Wei,Cheng Ke,Maoxu Hua,Zhang Minghong. Effects of total iridoid glycosides in Gardenia jasminoides on the expression of AQP4 and MMP-2/9 in perihematomal brain regions of rats[J]. Pharmacology and Clinics of Chinese Materia Medica, 2010, 0(2) |
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| Authors: | Yang Kui Dai Yang Wu Chunjiu Xiang Liang Huang Wei Cheng Ke Maoxu Hua Zhang Minghong |
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| Affiliation: | Yang Kui1,2,Dai Yang2,Wu Chunjiu2,Xiang Liang2,Huang Wei2,Cheng Ke2,Maoxu Hua2,Zhang Minghong2(1 Chengdu University of TCM,Chengdu 610072,2 Chengdu Baikang Research Institute of Pharmarcology , Toxicology,Chengdu 610046) |
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| Abstract: | Objective:To study the influence of total iridoid glycosides in Gardenia jasminoides on the expression of AQP4 and MMP-2/9 in perihematomal brain regions of rats. Methods:Male Sprague-Dawley rats were randomly divided into pseudo-operation group,ICH model group and the treatmengt group of Gardenia jasminoides total iridoid glycosides (30 mg/kg). ICH models were induced in rats by injecting stereotactic infusion autologous blood into pallidus. The brain tissue specments of 5 rats in every group were respecti... |
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| Keywords: | total iridoid glycosides in Gardenia jasminoides intracerebral hemorrhage aquaporin-4 matrix metalloproteinases-2/9 |
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