速眠新麻醉对家兔的生理影响

目的探讨速眠新（SMX）用于家兔麻醉对血流动力学、血液学、血液生化、血气指标的影响。方法首先抽取麻醉前正常状态下家兔静脉血、动脉血。检测血液学、血生化学、血气指标。后以速眠新0．2mL／kg体重肌内注射于兔后肢肌肉丰厚处，3min左右，家兔处于制动状态，于麻醉后进行兔颈动脉插管监测平均动脉血压（MAP），无刨心电监护仪监测呼吸（RR）、心率（HR）。15min时，抽取兔耳缘静脉血测血液学、血生化指标；抽取兔耳中动脉血测血气指标。结果（1）血液学指标：麻醉后较麻醉前红细胞平均血红蛋白浓度（MCHC）（P〈0．05）、血小板比积（PCT）（P〈0．05）显著升高，红细胞体积宽度值（RDW—CV）（P〈0．05）显著降低。（2）血生化指标：麻醉后较麻醉前肌酐（Cr）（P〈0．01）降低，葡萄糖（GLu）（P〈0．05）、肌酸激酶（CK）（P〈0．05）、肌酸激酶同工酶（CK—MB）（P〈0．05）、镁（Mg）（P〈0．05）、磷（P）（P〈0．01）显著升高。（3）血气分析：麻醉后较麻醉前二氧化碳分压（Pc02）（P〈0．01）、碳酸氢根（HCO3^-）（P〈0．05）、总二氧化碳量（1、C02）（P〈0．05）、细胞外液剩余碱（BEeef）（P〈0．05）显著升高，麻醉后较麻醉前钾（K）（P〈0．05）显著降低。（4）血流动力学：麻醉后较麻醉前平均动脉压（MAP）、呼吸（RR）、心率（HR）均降低。结论速眠新用于家兔麻醉对其血液学、血液生化、血气指标、血流动力学均有影响。

Influence of Sumianxin Anesthesia on Physiology in Rabbits

Objective To explore the influence of Sumianxin(SMX),a composite anesthetic,anesthesia on haemodynamics,hematology,blood biochemical and blood gas indexes in rabbit. Methods Arterial and venous blood samples of the rabbits were collected before and after anesthesia with SMX to analyze the changes of hematologic,blood biochemical and blood gas parameters.The SMX was injected at a dose of 0.2 mL/kg body weight into the hind leg muscles of the rabbits.Three minutes later,the rabbits became anesthized.The carotid artery was cannulated to monitor the arterial blood pressure in each rabbit.The respiration rate and heart rate were monitored by the non-invasive electrocardiogram monitor.15 minutes after anesthesia,the arterial and venous blood samples of the rabbits were drawn for hematology,blood biochemical and blood gas analyses.Result 1.Compared with those before anesthesia,MCHC,PCT increased,and RDW-CV decreased significantly after anesthesia(P<0.05).The changes of hematological parameters were not significantly(P>0.05).2.Compared with those before anesthesia,Cr decreased very significantly after anesthesia(P<0.01),GLU,CK,CK-MB increased significantly(P<0.05),Mg increased significantly(P<0.05),and P increased very significantly(P<0.01).Other indexes of blood biochemicals were not changed significantly(P>0.05).3.Compared with those before anesthesia,PCO_2 increased very significantly(P<0.01),TCO_2,Beecf and HCO~-_3 increased significantly(P<0.01),and K~ decreased significantly after anesthesia(P<0.05).Other indexes of blood gas analysis were not increased or decreased significantly(P>0.05).4.Compared with those before anesthesia,MAP,RR,HR decreased after anesthesia.Conclusion Hemodynamics,hematology,serum biochemicals and blood gas were significantly influenced by SMX anesthesia in rabbits.