| 替罗非班在老年急性心肌梗死临床应用的有效性及安全性研究 |
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| 引用本文： | 高振华,袁如玉,李广平.替罗非班在老年急性心肌梗死临床应用的有效性及安全性研究[J].中国全科医学,2011,14(21). |
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| 作者姓名： | 高振华 袁如玉 李广平 |
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| 作者单位： | 天津医科大学第二医院心脏科,天津市,300211 |
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| 摘 要： | 目的 评价老年急性ST段抬高型心肌梗死患者在经皮冠状动脉介入治疗(PCI)中应用血小板膜糖蛋白IIb/IIIa受体拮抗剂替罗非班的有效性及安全性.方法 87例急性ST段抬高型心肌梗死患者,随机分为用药组(替罗非班+PCI)和对照组(PCI),分别比较两组患者基础资料,术中不良事件、罪犯血管术后TIMI血流分级、PCI术后1 h梗死相关导联ST段回落、PCI术后1周心脏超声、出血事件、30 d内不良事件、1年内不良心血管事件(再发心绞痛、心肌梗死、再次血运重建、猝死)及心功能状态等.结果 两组术后TIMI3级血流发生率、1 h心电图梗死相关导联ST段回落＞50%发生率、30 d内不良事件、1年内再次血运重建、1年后心功能状态NYHA 1级的发生率比较,用药组优于对照组,差异均有统计学意义(P＜0.05).用药组患者出现出血事件8例(17.0%),对照组3例(7.5%),两组出血率比较,差异无统计学意义(P＞0.05).结论 老年急性ST段抬高型心肌梗死患者行PCI治疗中使用替罗非班是安全有效的.
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| 关 键 词： | 冠心病 心肌梗死 替罗非班 |
Safety and Efficacy of Tirofiban in Elder Patients with Acute Myocardial Infarction |
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| GAO Zhen-hua,YUAN Ru-yu,LI Guang-ping.Safety and Efficacy of Tirofiban in Elder Patients with Acute Myocardial Infarction[J].Chinese General Practice,2011,14(21). |
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| Authors: | GAO Zhen-hua YUAN Ru-yu LI Guang-ping |
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| Institution: | GAO Zhen-hua,YUAN Ru-yu,LI Guang-ping.Department of Cardiology,2nd Affiliated Hospital of Tianjin Medical University,Tianjin 300211,China |
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| Abstract: | Objective To evaluate the efficacy and safety of glycoprotein IIb/IIIa inhibitor(tirofiban) in elder patients with acute ST-elevation myocardial infarction(STEMI) receiving PCI.Methods Eighty-seven STEMI patients were randomly divided into two groups:experimental group(tirofiban+PCI) and control group(PCI).General information,adverse events during PCI,coronary reperfusion flow(TIMI grades)of the culprit vessel after PCI,the ST-segment drop of leads correlated infraction one hour after PCI,ultrasound cardiog... |
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| Keywords: | Coronary disease Myocardial infarction Tirofiban |
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