| 新诊断2型糖尿病患者血清视黄醇结合蛋白4和游离脂肪酸水平变化及其与胰岛素敏感性的关系研究 |
| |
| 引用本文： | 潘佳秋,王慧慧,张超,于学静,姜飞飞.新诊断2型糖尿病患者血清视黄醇结合蛋白4和游离脂肪酸水平变化及其与胰岛素敏感性的关系研究[J].中国全科医学,2011,14(21). |
| |
| 作者姓名： | 潘佳秋 王慧慧 张超 于学静 姜飞飞 |
| |
| 作者单位： | 佳木斯大学附属第一医院内分泌科,黑龙江省佳木斯市,154002 |
| |
| 摘 要： | 目的 探讨新诊断2型糖尿病(T2DM)患者血清视黄醇结合蛋白4(RBP4)和游离脂肪酸(FFA)的表达水平以及二者与胰岛素敏感性的关系.方法 选取新诊断T2DM患者76例(T2DM组)及健康体检者30例(对照组).观察各组空腹血清RBP4和FFA水平,并计算胰岛素抵抗指数(HOMA-IR)、胰岛素敏感性指数(ISI)用以评价各组胰岛素敏感性.结果 (1)T2DM组患者血清RBP4和FFA水平显著高于对照组(P＜0.01).(2)单因素相关分析显示,血清RBP4与体质指数(BMI)、三酰甘油(TG)、总胆固醇(TC)、HOMA-IR、FFA呈正相关,与ISI、HOMA-β呈负相关(P＜0.05).(3)多元逐步回归分析发现,HOMA-IR、FFA作为独立危险因素影响血清RBP4水平,常数项为零.结论 T2DM患者血清RBP4、FFA水平均显著升高;RBP4水平升高与糖脂代谢有关,从而导致胰岛素抵抗,进而参与T2DM的发生、发展.RBP4与FFA在胰岛素抵抗中可能起协同作用.
|
| 关 键 词： | 糖尿病 2型 视黄醇结合蛋白4 脂肪酸 非酯化 胰岛素敏感性指数 |
Changes of Serum Retinol Binding Protein 4 and Free Fatty Acids Levels among Newly Diagnosed Type 2 Diabetic Patients and the Correlations with Insulin-sensitivity |
| |
| PAN Jia-qiu,WANG Hui-hui,ZHANG Chao,et al..Changes of Serum Retinol Binding Protein 4 and Free Fatty Acids Levels among Newly Diagnosed Type 2 Diabetic Patients and the Correlations with Insulin-sensitivity[J].Chinese General Practice,2011,14(21). |
| |
| Authors: | PAN Jia-qiu WANG Hui-hui ZHANG Chao |
| |
| Institution: | PAN Jia-qiu,WANG Hui-hui,ZHANG Chao,et al.Department of Endocrinology,the First Affiliated Hospital of Jiamusi University,Jiamusi 154002,China |
| |
| Abstract: | Objective To explore the levels of serum retinol binding protein 4(RBP4) and free fatty acids(FFA),as well as the relationships between RBP4 level,FFA level and insulin-resistance index(ISI) in newly diagnosed type 2 diabetic patients.Methods Both Newly diagnosed type 2 diabetes patients(T2DM,n=76) and healthy subjects(NC,n=30) were enrolled grouping this study,with their serum levels of RBP4 and FFA measured.Also,insulin resistance index(HOMA-IR) and insulin sensitivity(ISI) were calculated in both groups.... |
| |
| Keywords: | Diabetic mellitus type 2 Retinol-binding protein 4 Fatty acids nonesterified Insulin-resistance index |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
