Effect of the Immune Modulators BM 12.531 (Azimexone) and BM 41.332 on the Subsets of T-Lymphocytes in Mice

Abstract

The immunomodulating 2-cyanaziridine derivatives BM 12.531 (azimexone) and BM 41.332 have no effects on the total amount of T-lymphocytes in the spleen of mice but ingrease dose-dependently the percentage of Ly1^?-, 2⁺, 3⁺ T-lymphocytes (killer/suppressor) and decrease the percentage of Ly1⁺, 2^?-, (helper) cells. These investigations were carried out by means of specific monoclonal antibodies and fluoreqcence-activated cell sorting. The increase in Ly2⁺-cells is mainly due to increased suppressor activity.