慢性阻塞性肺疾病患者血浆Clara细胞分泌蛋白水平的变化及其与动脉血气的相关性

目的:探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者血浆Clara细胞分泌蛋白(Clara cell secretory protein,CC16)水平变化及其与动脉血气的关系.方法:回顾性分析2019年3月至2020年6月上海市宝山区仁和医院收治的94...

Changes of plasma Clara cell secretory protein level and its relationship with arterial blood gas in patients with chronic obstructive pulmonary disease

[Abstract] Objective: To investigate the changes of plasma Clara cell secretory protein (CC16) and its relationship with arterial blood gas [Arterial oxygen pH (pH), arterial partial pressure of oxygen (PaO2), Arterial partial pressure of carbon dioxide (PaCO2), Arterial oxygen saturation (SaO2)] in patients with chronic obstructive pulmonary disease (COPD). Methods: The clinical data of COPD patients admitted to our hospital from March 2019 to June 2020 were retrospectively analyzed, including 49 cases of stable COPD and 45 cases of acute exacerbation. The physical examination data of 43 healthy people in the same period were retrospectively analyzed and recorded as group A, group B and group C respectively. The levels of plasma CC16 were compared among the three groups. The levels of arterial blood gas related parameters were compared among the three groups. Pearson correlation analysis was used to explore the correlation between the changes of plasma CC16 levels and arterial blood gas related parameters in stable and acute exacerbation of COPD patients and total COPD patients. Results: The levels of plasma CC16 in group A and group B were significantly lower than those in group C (P < 0.05), and those in group B were significantly lower than those in group A (P < 0.05). The differences of pH, PaO2 and SaO2 levels among the three groups were statistically significant (P < 0.05). The levels of pH, PaO2 and SaO2 in group A and B were lower than those in group C (P < 0.05), and those in group B were significantly lower than those in group A (P < 0.05). The levels of PaCO2 in group A and B were significantly higher than that in group C (P < 0.05), and that in group B was significantly higher than that in group A (P < 0.05). The levels of plasma CC16 were positively correlated with pH, PaO2 and SaO2 in stable and acute exacerbation of COPD patients and total COPD patients (stable: r = 0752, 0.824, 0.874; acute exacerbation: r = 0.768, 0.856, 0.917; total COPD patients: r = 0.759, 0.839, 0.887, and all Ps < 0.05), but negatively correlated with PaCO2 (stable: r = -0.819, acute exacerbation: r = -0.835; total COPD patients: r = -0.820, and all Ps < 0.05). Conclusion: There were significant changes in plasma CC16 level and arterial blood gas related parameters in patients with stable and acute exacerbation of COPD, and the change range of patients with acute exacerbation of COPD was significantly greater than that of stable COPD. There was a correlation between plasma CC16 level and arterial blood gas related parameters in patients with stable and acute exacerbations of COPD.