老年患者铜绿假单胞菌医院感染的危险因素与耐药性分析

目的探讨254例老年患者铜绿假单胞菌（PAE）医院感染的危险因素及耐药性,为临床监测与控制PAE感染提供依据。方法统计老年患者PAE医院感染的临床资料,采用K-B法对PAE进行体外耐药监测。结果老年患者PAE医院感染的危险因素为原发基础疾病、免疫功能低下、住院日长、侵入性治疗、抗菌药物使用时间长等;PAE对复方新诺明和头孢噻肟耐药率分别为74.8%、60.2%,对亚胺培南耐药率为3.9%。结论建议采取综合治理措施,控制耐药菌的传播,提高对老年患者PAE感染的防治水平。

Nosocomial Infection and Antimicrobial Resistance of Pseudomonas aeruginosa among Geriatrics Patients

OBJECTIVE To investigate nosocomial infection and antibiotic resistance of Pseudomonas aeruginosa among geriatrics patients and to instruct clinical monitoring and control infection. METHODS P. aeruginosa isolates from geriatrics patients were identified and the resistance to antibiotics was determined by K-B method. RESULTS The risk factors of nosocomial infection were underlying diseases, low immunological function, long time hospitalization, invasive treatment, and prolonged antibiotic therapy. The resistant rates to trimethoprim/ sulfarnethoxazole and cefotaxime in PA were 74.8% and 60.2%, respectively. The resistance rate to imipenem was 3.9 %. CONCLUSIONS It is suggested to carry out proper measurement to control the spread of multiresistant strains in order to improve the treatment of PAE infection in geriatrics patients.