Dietary fat saturation affects hepatocyte insulin binding and glucose metabolism in BHE rats |
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Authors: | J S Pan C D Berdanier |
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Affiliation: | Department of Foods and Nutrition, University of Georgia, Athens 30602. |
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Abstract: | The influence of feeding 6% hydrogenated coconut oil, corn oil or menhaden oil on hepatocyte insulin binding, receptor number and glucose use was studied. Hepatocytes isolated from rats fed menhaden oil had a significantly greater affinity for insulin than hepatocytes from rats fed hydrogenated coconut oil. Glucose use was not influenced by diet; uniformly labeled glucose was metabolized to CO2 or to lipid similarly in cells isolated from rats fed the three oils. Thus, dietary fat type in a low fat diet influenced events at the plasma membrane without influencing intracellular events. |
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