血清淀粉样蛋白A与胰岛素抵抗及糖尿病肾病

研究提示,胰岛素抵抗和糖尿病肾病都是慢性非特异性炎性反应过程.血清淀粉样蛋白A(SAA)作为一种急性时相反应蛋白,能够刺激多种免疫活细胞,产生大量炎性细胞因子,介导炎性反应,并能诱导单核细胞表达趋化因子,使各种炎性细胞尤其是单核/巨噬细胞及T细胞聚集到病变部位.而这种免疫和炎性反应过程可能促进了胰岛素抵抗和糖尿病肾病的发生和发展.

Serum amyloid A, insulin resistance and diabetic nephropathy

Studies have suggested that insulin resistance and diabetic nephropathy are processes of chronic nonspecfic inflammation. Serum amyloid protein A (SAA), as an acute phase protein, can stimulate a variety of immune living cells to secrete a large number of inflammatory cytokines which can mediate inflammatory response. SAA induces monocyte cells to express chemokines, and is also involved in the recruitment of monocytes macrophages and T cells into the pathological sites. The immune reaction and inflammation may further promote the development of insulin resistance and diabetic nephropathy.