丹参酮IIA磺酸钠注射液联合降脂方治疗非酒精性脂肪肝疗效观察

目的:观察丹参酮IIA磺酸钠注射液联合降脂方治疗非酒精性脂肪肝的临床疗效。方法:将60例患者随机分为2组各30例,试验组予丹参酮IIA磺酸钠注射液静脉滴注,并口服中药降脂方;对照组予阿托伐他汀钙口服,观察比较2组患者治疗前与治疗4周后肝/脾CT值、甘油三酯、总胆固醇及中医证候积分变化。结果:治疗后2组患者肝/脾CT值、甘油三酯、总胆固醇、中医证候积分均较治疗前明显改善(P0.05);治疗组各项指标改善较对照组更为显著(P0.05)。结论:丹参酮IIA磺酸钠注射液联合降脂方能改善患者临床症状及肝/脾CT值、甘油三酯、总胆固醇,疗效优于阿托伐他汀钙。

Therapeutic Effect of Tanshinone IIA Sulfonate Injection Combined with Jiangzhi Formula for Non-alcoholic Fatty Liver Disease

Objective： To observe the clinical efficacy of Tanshinone IIA Sulfonate Injection combining with ]iangzhi formula for non-alcoholic fatty liver disease（NAFLD）. Methods： Sixty cases were randomly divided into two groups. Thirty cases in the experimental group received intravenous injection of Tanshinone II A Sulfonate Injection combined with oral use of Jiangzhi formula orally, and 30 cases in the control group were treated with Atorvastatin orally. Liver/spleen CT values, serum total cholesterol（TC）, triglyceride（TG） and the Chinese medical syndrome scores were observed. Results： After treatment, the liver/spleen CT values, TC, TG and CM syndrome scores were improved significantly in both groups（P 〈 0.05）, and the improvement of indexes in the experimental group was superior to that in the control group（P〈 0.05）. Conclusion： Tanshinone IIA Sulfonate Injection combined with Jiangzhi formula had better effect on relieving the clinical symptoms and on improving- liver/spleen CT values, serum levels of TC and TG than Atorvastatin.