静息态功能MRI观察脑梗死后失语症患者功能连接变化

目的 采用静息态功能MRI（rs-fMRI）观察脑梗死后失语患者各脑区功能连接（FC）变化。方法 对10例脑梗死后失语症患者（观察组）及10名健康志愿者（对照组）采集rs-fMRI，以左侧额下回（LIFG）布罗卡（Broca）区为种子点，分析组内和组间ROI与其他脑区FC相关性的差异。结果 对照组双侧枕叶、顶叶、额叶、颞叶、小脑半球、小脑扁桃体及脑干与ROI FC呈正相关（P均<0.05）；观察组双侧额下回，左侧中央后回、中央前回、额中回、扣带回、豆状核、海马、楔叶、枕叶，右侧顶下小叶、缘上回与ROI的FC呈正相关（P均<0.05）；观察组双侧缘上回、颞下回、梭状回、顶下小叶、枕中回，右侧额中回、扣带回、小脑半球，左侧颞中回、颞上回等与ROI的FC的相关性高于对照组（P均<0.05）。结论 静息态下健康人脑内存在语言功能网络；左侧脑梗死后失语症患者多个脑区与LIFG Broca区的FC呈正相关，以左侧大脑半球额叶为主，可能与脑梗死后失语症的发生及恢复机制有关。

Resting state functional MRI observation on functional connectivity in aphasia patients after cerebral infarction

Objective To observe the changes of functional connectivity (FC) in aphasia patients after cerebral infarction with resting-state functional MRI (rs-fMRI). Methods Ten aphasia patients after cerebral infarction (observation group) and 10 healthy volunteers (control group) underwent rs-fMRI scanning. The Broca''s area of the left inferior frontal gyrus (LIFG) was taken as the seed point, and the differences of FC correlation between ROI and other brain regions were compared within group and between groups. Results Bilateral occipital lobes, parietal lobes, frontal lobes, temporal lobes, cerebellar hemispheres, cerebellar tonsils and brainstem in control group were positively correlated with FC of ROI (all P<0.05), while bilateral inferior frontal gyrus, left posterior central gyrus, anterior central gyrus, middle frontal gyrus, cingulate gyrus, lenticular nucleus, hippocampus, wedge lobe, occipital lobe, right inferior parietal lobule and superior marginal gyrus in observation group were positively correlated with FC of ROI (all P<0.05). Bilateral supramarginal gyrus, inferior temporal gyrus, fusiform gyrus, inferior parietal lobule, middle occipital gyrus, right middle frontal gyrus, cingulate gyrus, cerebellar hemispheres, left middle temporal gyrus, superior temporal gyrus, etc. had higher correlation with FC of ROI in observation group than those in control group (all P<0.05). Conclusion Resting-state language functional networks existed in healthy human brain. Multiple brain regions of aphasia patients after left cerebral infarction were positively correlated with FC of Broca''s area of LIFG, mainly distributed in the left frontal lobe, which might be related to the occurrence and recovery mechanism of aphasia after cerebral infarction.