男性骨质疏松与冠心病相关性的Meta分析

目的运用Meta分析探究男性骨质疏松与冠心病之间的关系。方法检索中外文献数据库,包括Pubmed、Cochrane、Embase、CNKI、万方数据库、维普中文科技期刊全文数据库(VIP)和中国生物医学文献数据库(CBM)等,检索时间自建库至2020年6月,通过纳入、排除标准筛选合适的文献,根据Newcastle-Ottawa Scale (NOS)量表评价文献质量,应用Review Manager5.3软件进行数据分析。结果最终纳入11篇文献,共涉及1 962例患者,包括骨质疏松组603例,非骨质疏松组(骨量减少和骨量正常) 1 359例。Meta分析结果发现,男性骨质疏松组冠心病的发病率显著高于非骨质疏松组(OR=1.43,95%CI 1.14～1.79,P0.05);根据患者不同年龄段进行亚组分析,中年男性骨质疏松组冠心病的发病率与非骨质疏松组相比无统计学意义(OR=0.92,95%CI 0.23～3.69,P 0.05),但老年男性骨质疏松组冠心病的发病率显著增高(OR=1.86,95%CI1.12～3.08,P0.05);根据患者不同骨量减少程度进行亚组分析,中、老男性骨量减少组冠心病的发病率与骨量正常组相比均无统计学意义(中年男性OR=1.25,95%CI 0.66～2.36,P0.05;老年男性OR=1.11,95%CI 0.35～3.53,P0.05)。结论老年男性骨质疏松与冠心病的发病率密切相关,中年男性骨质疏松与冠心病的发病率无明显相关性,且中、老年男性骨量减少与冠心病的发病率无明显相关性。

Meta-analysis of the relationship between osteoporosis and coronary heart disease in males

Objective To explore the relationship between osteoporosis (OP) and coronary heart disease (CHD) in males using meta-analysis method. Methods International and domestic documentary databases, including Pubmed, Cochrane, Embase, CNKI, Wanfang Data, CQVIP, and CBM, were searched. The retrieval time was from the founding of databases to June 2020. The screened reviews and literature were evaluated according to inclusion and exclusion criteria. The quality of data was assessed according to the Newcastle-Ottawa scale (NOS) and analyzed with a Review Manager 5.3 software. Results A total of 11 papers were included. A total of 1962 patients, 603 cases of osteoporosis, and 1359 cases of non-osteoporosis (osteopenia and normal) were involved. Meta-analysis showed that the incidence of CHD in males was significantly higher in osteoporosis group than that in non-osteoporosis group (OR=1.43, 95%CI 1.14-1.79, P<0.05). In the age-stratified subgroup analysis, there was no statistical significance of occurrence of CHD between osteoporosis and non-osteoporosis group in middle-aged males (OR=0.92, 95%CI 0.23-3.69, P>0.05), while in elderly males the incidence of CHD was much higher (OR=1.86, 95%CI 1.12-3.08, P<0.05). In the subgroup analysis stratified by osteopenia, there was no statistical significance of occurrence of CHD between osteopenia and normal group in middle-aged and elderly males (middle-aged males: OR=1.25, 95%CI 0.66-2.36, P>0.05; elderly males: OR=1.11, 95%CI 0.35-3.53, P>0.05, respectively). Conclusion The incidence of CHD in elderly males is remarkably correlated with osteoporosis, while it is uncorrelated with osteoporosis in middle-aged males. The incidence of CHD is uncorrelated with osteopenia in middle-aged and elderly males.