Effects of CuCl2 on the dimer-tetramer equilibrium of concanavalin A

Tetrameric concanavalin A at neutral pH dissociated into the dimer when CuCl₂ was added in a concentration range comparable to protomer concentration. This effect of CuCl₂ was largely suppressed when NaCl concentration was increased. Neither the conformation of the protein nor its binding activity to 4-methylumbelliferyl α-D-man-nopyranoside was affected on addition of CuCl₂.